Is Agave Gluten Free?
Yes, agave is naturally gluten-free. As a plant-derived sweetener made from the agave plant, it does not contain any wheat, barley, rye, or other gluten-containing grains.
Low glycemic index: Agave has a lower glycemic index compared to regular sugar, potentially causing less dramatic spikes in blood sugar levels.
Natural sweetener: It can be used as an alternative to refined sugar in various recipes.
Contains some nutrients: Agave contains small amounts of vitamins and minerals, including vitamin C, iron, and calcium.
May have anti-inflammatory properties: Some compounds in agave might help reduce inflammation in the body.
Potential prebiotic effects: Agave contains inulin, a type of fiber that may support gut health by promoting beneficial bacteria growth.
Vegan-friendly sweetener: It’s plant-based and suitable for vegan diets.
Potential antioxidant properties: Some studies suggest agave may contain antioxidants that could help protect cells from damage.
May support wound healing: Traditionally used topically for wound care in some cultures.However, it’s important to note that agave is still high in fructose and should be consumed in moderation. The health benefits are often outweighed by its high sugar content when consumed in large amounts. Always consult with a healthcare professional for personalized dietary advice.
People with diabetes or pre-diabetes, as agave can significantly impact blood sugar levels
Individuals with fructose intolerance or malabsorption
Those with irritable bowel syndrome (IBS), as high-fructose foods can trigger symptoms
People trying to lose weight or manage their calorie intake, as agave is high in calories
Individuals with a history of metabolic disorders
Those with liver disease or at risk for fatty liver disease
People with hereditary fructose intolerance (HFI)
Individuals following a low-FODMAP diet
Those with known allergies to agave or plants in the Asparagaceae family
Pregnant women, as there’s limited research on its safety during pregnancy
Young children, due to its high fructose content
People with dental issues or at high risk for tooth decay, as agave can contribute to cavitiesAlways consult with a healthcare professional before making significant changes to your diet, especially if you have pre-existing health conditions.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.