Allegra, a brand name antihistamine medication containing the active ingredient fexofenadine, is generally considered gluten-free. However, it’s always best to check the specific product packaging or consult with the manufacturer or a healthcare professional to confirm, as formulations can sometimes change or vary between different versions of the medication.

Relieves allergy symptoms such as sneezing, runny nose, itchy or watery eyes, and itchy throat or nose
Reduces hay fever symptoms
Treats hives (urticaria) and associated itching
Provides non-drowsy relief, unlike some other antihistamines
Offers 24-hour relief with a single dose
Does not cause significant drowsiness or impairment of cognitive function
Has a low risk of drug interactions compared to some other antihistamines
Can be used by adults and children (age 6 and older for allergies, 12 and older for hives)
Helps improve quality of life for allergy sufferers
May reduce the need for nasal corticosteroids in some patients
Can be taken with or without food
Doesn’t typically cause dry mouth, a common side effect of some antihistamines
Has a rapid onset of action, often providing relief within 1-3 hoursRemember, while Allegra offers these benefits, it’s always best to consult with a healthcare professional before starting any new medication.
Those with known hypersensitivity or allergy to fexofenadine or any of its ingredients
Patients with severe kidney disease, as the drug is primarily excreted through the kidneys
Pregnant women, unless the potential benefit outweighs the risk (Category C drug)
Breastfeeding mothers, as it’s unclear if the drug passes into breast milk
Children under 6 months old for Allegra oral suspension, or under 2 years old for other formulations
People taking certain antacids containing aluminum or magnesium hydroxide, as these can decrease Allegra’s effectiveness
Individuals with phenylketonuria (PKU) should avoid certain formulations of Allegra that contain aspartame
Those with rare hereditary problems of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption
People taking certain antibiotics like erythromycin or rifampicin, as these can affect Allegra’s levels in the body
Individuals with a history of Long QT syndrome, as antihistamines may potentially affect heart rhythmAlways consult with a healthcare provider before starting or stopping any medication, as individual health conditions and medications can affect the appropriateness of using Allegra.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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