Benadryl is generally considered gluten-free, as it does not contain wheat, barley, rye, or oats in its active or inactive ingredients. However, it’s always best to check the specific product labeling or consult with the manufacturer directly to confirm, especially if you have celiac disease or severe gluten sensitivity.

Allergy relief: Reduces symptoms of hay fever and other allergies, such as sneezing, runny nose, and itchy eyes
Treatment of hives: Helps relieve itching and swelling associated with hives
Insomnia relief: Can be used as a short-term sleep aid due to its sedative effects
Motion sickness prevention: Helps reduce nausea and vomiting associated with motion sickness
Cold symptom relief: Can alleviate some symptoms of the common cold, such as runny nose and sneezing
Itching relief: Provides relief from itching caused by insect bites, poison ivy, or other skin irritations
Cough suppression: May help reduce coughing, especially nighttime coughs that disrupt sleep
Vertigo treatment: Can help alleviate symptoms of vertigo in some cases
Parkinson’s disease: May help manage certain symptoms in some Parkinson’s patients
Nausea relief: Sometimes used to treat nausea and vomiting, particularly in conjunction with other medicationsIt’s important to note that while Benadryl has these potential benefits, it should always be used as directed and under the guidance of a healthcare professional, as it can have side effects and interactions with other medications.
Infants and children under 2 years old
Pregnant women, especially in the first trimester
Breastfeeding mothers
People with glaucoma
Individuals with enlarged prostate or urinary retention issues
Those with chronic obstructive pulmonary disease (COPD) or asthma
People with liver disease
Individuals with hyperthyroidism
Those with cardiovascular disease or high blood pressure
People taking monoamine oxidase inhibitors (MAOIs)
Individuals with a history of seizures
Those with porphyria (a rare blood disorder)
People with gastrointestinal obstruction or stenosis
Individuals with known hypersensitivity or allergy to diphenhydramine
Elderly individuals, due to increased risk of side effects
People operating heavy machinery or driving, due to drowsiness
Those with a history of alcohol or substance abuseAlways consult with a healthcare professional before taking Benadryl, especially if you have any pre-existing medical conditions or are taking other medications.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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