Traditional Bisquick is not gluten-free as it contains wheat flour. However, Betty Crocker does produce a separate gluten-free version of Bisquick made with rice flour, which is clearly labeled as “Gluten Free Bisquick” on the package.

Convenience: Can save time and effort in meal preparation, potentially reducing stress.
Fortified ingredients: Some versions may contain added vitamins and minerals.
Versatility: Can be used to make a variety of dishes, potentially increasing home-cooked meal frequency.
Low in sugar: The base mix doesn’t contain added sugars.
Can be part of a balanced diet when used in moderation.However, it’s important to note that Bisquick is not particularly nutrient-dense and contains refined flour and oils. For significant health benefits, it’s better to focus on whole, unprocessed foods. Always consult with a healthcare professional or nutritionist for personalized dietary advice.
People with celiac disease or gluten sensitivity (as regular Bisquick contains wheat flour)
Individuals with wheat allergies
Those following a low-carb or ketogenic diet
People with diabetes who need to carefully monitor their carbohydrate intake
Individuals trying to avoid processed foods
Those with milk allergies or lactose intolerance (as Bisquick contains milk)
People following a vegan diet (due to the milk content)
Individuals with soy allergies (as some varieties may contain soy)
Those trying to avoid added sugar in their diet
People with egg allergies (if using Bisquick in recipes that call for eggs)
Individuals following a paleo or whole food-based diet
Those with sensitivities to certain preservatives or additivesNote that there are gluten-free and other alternative versions of Bisquick available, which may be suitable for some of these groups. Always check the ingredient list and consult with a healthcare professional if you have specific dietary concerns or restrictions.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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