Most bitters are gluten-free as they are typically made from herbs, spices, and alcohol derived from non-gluten sources. However, it’s always best to check the specific brand and ingredients list, as some bitters may contain gluten-containing additives or be produced in facilities that process gluten.

Improved digestion: Bitters can stimulate the production of digestive enzymes and stomach acid, aiding in better digestion.
Reduced bloating and gas: By promoting digestive efficiency, bitters may help alleviate uncomfortable digestive symptoms.
Appetite regulation: Bitters can help stimulate appetite before meals and reduce cravings after eating.
Liver support: Some bitter herbs are believed to support liver function and aid in detoxification processes.
Blood sugar regulation: Certain bitter compounds may help balance blood sugar levels.
Anti-inflammatory properties: Some bitter herbs have anti-inflammatory effects, which may benefit overall health.
Increased nutrient absorption: By improving digestion, bitters may enhance the body’s ability to absorb nutrients from food.
Stress reduction: Some bitter herbs have adaptogenic properties that may help the body cope with stress.
Improved gut health: Bitters may support the growth of beneficial gut bacteria.
Potential weight management aid: By regulating appetite and improving digestion, bitters might indirectly support weight management efforts.
Antioxidant properties: Many bitter herbs contain antioxidants that can help protect cells from damage.
Support for the immune system: Some bitter herbs may have immune-boosting properties.Remember that while these benefits are reported, scientific evidence varies, and it’s always best to consult with a healthcare professional before using bitters for medicinal purposes.
Pregnant women: Many bitters contain herbs and botanicals that may not be safe during pregnancy.
Breastfeeding mothers: Some ingredients in bitters may pass through breast milk.
People with liver disease: The liver processes many of the compounds found in bitters, so those with liver issues should consult a doctor.
Individuals with stomach ulcers or acid reflux: Bitters can stimulate stomach acid production, potentially exacerbating these conditions.
People taking certain medications: Bitters may interact with some medications, particularly blood thinners or drugs metabolized by the liver.
Those with allergies to specific herbs or botanicals: Some people may be allergic to ingredients commonly found in bitters.
Individuals with gallbladder issues: Bitters can stimulate bile production, which may be problematic for some gallbladder conditions.
Children: Due to the alcohol content and potent herbs, bitters are generally not recommended for children.
Recovering alcoholics: Most bitters contain alcohol and could potentially trigger a relapse.
People with certain autoimmune disorders: Some herbs in bitters may stimulate the immune system, which could be problematic for certain conditions.Always consult with a healthcare professional before using bitters if you have any health concerns or are taking medications.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
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Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.