Caramel color is generally considered gluten-free, as it is typically made from corn or other gluten-free sources. However, it’s always best to check with the manufacturer or look for certified gluten-free products if you have celiac disease or gluten sensitivity, as manufacturing processes can vary.

Caramel color is one of the oldest and most widely used food colorings.
It’s used to add brown color to various foods and beverages.
There are four classes of caramel color (I, II, III, and IV), each made using different processes.
Some concerns have been raised about potential health risks associated with certain types of caramel color, particularly those containing 4-methylimidazole (4-MEI).
Regulatory bodies like the FDA consider caramel color generally safe for use in food, but ongoing research continues to evaluate its long-term effects.
People with allergies or sensitivities to caramel coloring: Some individuals may experience allergic reactions or sensitivities to caramel coloring.
Those with sulfite sensitivities: Some types of caramel coloring (Class I and II) may contain sulfites, which can cause reactions in sensitive individuals.
Individuals with concerns about 4-methylimidazole (4-MEI): Some types of caramel coloring (Class III and IV) may contain 4-MEI, which has been linked to cancer in animal studies. Those concerned about potential health risks may choose to limit their exposure.
People following a low-FODMAP diet: Caramel coloring may contain FODMAPs, which can trigger digestive issues in sensitive individuals.
Individuals with phenylketonuria (PKU): Some caramel colorings may contain phenylalanine, which should be avoided by those with PKU.
Those following a strict vegan diet: Some caramel colorings may be derived from animal sources, so vegans should check the source of the coloring.
Individuals with digestive sensitivities: Some people may experience gastrointestinal discomfort after consuming products with caramel coloring.
People trying to reduce their intake of artificial additives: Those looking to minimize their consumption of food additives may choose to avoid or limit caramel coloring.
Individuals with specific religious or cultural dietary restrictions: Depending on the source and production method, some caramel colorings may not be suitable for certain religious or cultural diets.It’s important to note that for most people, caramel coloring is considered safe when consumed in moderation as part of a balanced diet. However, individuals with specific health concerns or dietary restrictions should consult with a healthcare professional or registered dietitian for personalized advice.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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