Yes, coffee is naturally gluten-free. Pure, plain coffee beans do not contain gluten, making coffee a safe beverage choice for people with celiac disease or gluten sensitivity.

Boosts energy and alertness
Improves cognitive function and mental performance
Contains antioxidants that may protect against cell damage
May lower the risk of type 2 diabetes
Potentially reduces the risk of Parkinson’s disease
May protect against Alzheimer’s disease and dementia
Can enhance physical performance and endurance
May support weight management and fat burning
Associated with a lower risk of depression
Potentially lowers the risk of certain types of cancer
May protect against liver diseases, including cirrhosis
Can increase longevity and lower the risk of premature death
Provides essential nutrients like riboflavin, pantothenic acid, and manganese
May reduce the risk of stroke
Can improve gut health and support beneficial gut bacteria
Potentially lowers the risk of heart disease
May enhance mood and well-beingRemember that while coffee has many potential benefits, individual responses can vary, and excessive consumption may lead to negative side effects. It’s always best to consume coffee in moderation as part of a balanced diet.
Pregnant women: High caffeine intake may increase the risk of miscarriage and low birth weight.
Breastfeeding mothers: Caffeine can pass through breast milk and affect the baby’s sleep patterns.
People with anxiety disorders: Caffeine can exacerbate anxiety symptoms.
Individuals with sleep disorders: Coffee can interfere with sleep quality and patterns.
Those with high blood pressure: Caffeine can cause short-term spikes in blood pressure.
People with certain heart conditions: Caffeine can increase heart rate and palpitations.
Individuals with gastroesophageal reflux disease (GERD): Coffee can worsen symptoms.
Those with irritable bowel syndrome (IBS): Coffee may trigger or worsen symptoms.
People taking certain medications: Coffee can interact with some drugs, including antibiotics and antidepressants.
Children and adolescents: Their developing bodies may be more sensitive to caffeine’s effects.
Those with caffeine sensitivity: Some people experience stronger reactions to caffeine.
Individuals with iron deficiency: Coffee can interfere with iron absorption.
People with glaucoma: Caffeine can increase eye pressure.Always consult with a healthcare professional for personalized advice regarding coffee consumption.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
Asked Questions 1
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.