Yes, collagen is generally considered gluten-free. Pure collagen protein does not contain gluten, which is a protein found in wheat, barley, and rye.

Improves skin health and elasticity
Reduces visible signs of aging, such as wrinkles and fine lines
Supports joint health and may reduce joint pain
Strengthens hair and nails
Promotes bone strength and density
May help increase muscle mass
Supports gut health and digestive function
Contributes to heart health by promoting arterial strength
May improve liver health
Supports brain health and may help prevent age-related cognitive decline
Aids in wound healing and tissue repair
May help with weight management by promoting feelings of fullness
Supports the health of blood vessels
Can improve the appearance of cellulite
May help reduce the risk of bone-related disorders like osteoporosis
Supports eye health, particularly the cornea and retina
Can contribute to better sleep quality
May help in the management of type 2 diabetes by improving blood sugar controlRemember that while collagen has many potential benefits, individual results may vary, and it’s always best to consult with a healthcare professional before starting any new supplement regimen.
Pregnant or breastfeeding women (due to limited research on safety)
People with fish, shellfish, or egg allergies (as some collagen supplements are derived from these sources)
Individuals with kidney stones or a history of kidney problems (as collagen may contain high levels of hydroxyproline, which can increase kidney stone formation)
Those with a history of calcium oxalate kidney stones (due to the potential increase in oxalate levels)
People following a vegetarian or vegan diet (as most collagen supplements are derived from animal sources)
Individuals with a sensitivity to MSG (monosodium glutamate), as some collagen peptides can have a similar effect
Those taking medications that interact with protein supplements (consult with a healthcare provider)
People with a history of hypercalcemia (high calcium levels in the blood)
Individuals with certain bleeding disorders (as collagen may affect blood clotting)
Those with a known allergy or sensitivity to collagen or its componentsAlways consult with a healthcare professional before starting any new supplement regimen, especially if you have pre-existing health conditions or concerns.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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