Is Enriched Flour Gluten Free?
Enriched flour is typically not gluten-free, as it is usually made from wheat which naturally contains gluten. To be considered gluten-free, flour must be made from gluten-free grains or have the gluten removed through special processing techniques.

Increased iron content, which helps prevent anemia and supports oxygen transport in the body
Added folic acid, which is crucial for preventing birth defects and supporting cell growth
Fortified with thiamin (vitamin B1), which aids in energy metabolism and nervous system function
Supplemented with riboflavin (vitamin B2), supporting cellular function and growth
Added niacin (vitamin B3), which helps with DNA repair and cellular energy production
Improved overall nutritional value compared to unenriched refined flour
May help prevent certain nutrient deficiencies in populations that rely heavily on wheat-based products
Can contribute to meeting daily recommended intakes of essential vitamins and minerals
Potentially reduces the risk of neural tube defects in developing fetuses when consumed by pregnant women
May help support cognitive function due to the added B vitaminsIt’s important to note that while enriched flour does offer these benefits, whole grain flour is generally considered more nutritious as it retains more of its natural nutrients and fiber.
Those with celiac disease or gluten sensitivity (if the enriched flour contains gluten)
Individuals following a low-carb or ketogenic diet
People trying to manage their blood sugar levels, such as diabetics
Those looking to reduce their intake of processed foods
Individuals with certain autoimmune conditions that may be exacerbated by refined grains
People following a whole foods-based diet
Those with specific nutrient sensitivities to added vitamins and minerals
Individuals with certain digestive issues that may be aggravated by refined grains
People trying to lose weight and control calorie intake
Those following specific dietary protocols like Paleo or Whole30
Individuals with wheat allergies (if the enriched flour is wheat-based)
People aiming to reduce inflammation in their bodies
Those looking to improve their overall nutrient intake through whole grains instead of refined options
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently Asked Questions
Our Expert
Drs. Ilse van Asperen
Drs. Ilse van Asperen is a medical doctor specialising in orthomolecular therapy and nutritional coaching. With a background in public and clinical health research and management, she focuses on addressing the root causes of health issues through diet, gut health, and stress reduction. As a professional editor for Little Helpers, she reviews all gluten-free content to ensure accuracy, safety, and scientific credibility. More about me
Our Sources
The information on this page is based on reputable health and nutrition organisations, ensuring accuracy and reliability for anyone following a gluten-free diet. For further details, see the sources below.
Sources
Experiences of our customers
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.