Is Excedrin Gluten Free?
Yes, Excedrin is generally considered gluten-free. However, it’s always best to check the specific product packaging or contact the manufacturer directly for the most up-to-date information, as formulations can sometimes change.

Pain relief: Effective for various types of pain, including headaches, migraines, menstrual cramps, toothaches, and minor arthritis pain
Fever reduction: Can help lower fever due to the acetaminophen component
Anti-inflammatory effects: Aspirin in Excedrin can reduce inflammation in the body
Improved mental alertness: The caffeine in Excedrin may help increase alertness and reduce fatigue
Faster onset of action: The combination of ingredients may provide quicker relief compared to single-ingredient pain relievers
Migraine management: Particularly effective for treating migraine headaches
Tension headache relief: Can help alleviate tension-type headaches
Sinus pain relief: May provide relief from sinus-related pain and pressure
Menstrual symptom relief: Can help reduce pain and discomfort associated with menstruation
Cold and flu symptom relief: May help alleviate some symptoms associated with colds and flu, such as headaches and body achesIt’s important to note that while Excedrin can provide these benefits, it should be used as directed and not exceed recommended dosages. Consult with a healthcare professional before using Excedrin, especially if you have any pre-existing medical conditions or are taking other medications.
Children under 12 years old (unless directed by a doctor)
Pregnant women, especially in the third trimester
Breastfeeding mothers
People with a history of stomach ulcers or bleeding disorders
Individuals with severe liver disease
Those with a history of alcohol abuse
People taking blood thinners (e.g., warfarin)
Individuals allergic to aspirin, acetaminophen, or caffeine
Those with phenylketonuria (PKU), as some Excedrin products contain aspartame
People with uncontrolled high blood pressure
Individuals taking monoamine oxidase inhibitors (MAOIs)
Those with a history of heart disease or stroke
People with asthma who are sensitive to aspirin
Individuals scheduled for surgery within two weeks
Those with kidney disease or impaired kidney functionAlways consult with a healthcare professional before taking any medication, especially if you have pre-existing health conditions or are taking other medications.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently Asked Questions
Our Expert
Drs. Ilse van Asperen
Drs. Ilse van Asperen is a medical doctor specialising in orthomolecular therapy and nutritional coaching. With a background in public and clinical health research and management, she focuses on addressing the root causes of health issues through diet, gut health, and stress reduction. As a professional editor for Little Helpers, she reviews all gluten-free content to ensure accuracy, safety, and scientific credibility. More about me
Our Sources
The information on this page is based on reputable health and nutrition organisations, ensuring accuracy and reliability for anyone following a gluten-free diet. For further details, see the sources below.
Sources
Experiences of our customers
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.