Is Fish Gluten Free?
Yes, fish is naturally gluten-free. However, it’s important to be cautious of any breading, marinades, or sauces used in preparing fish dishes, as these may contain gluten ingredients.

Rich source of high-quality protein
Excellent source of omega-3 fatty acids, particularly EPA and DHA
May lower risk of heart disease and stroke
Can help reduce blood pressure
May decrease risk of depression and other mental health disorders
Supports brain health and cognitive function
Good source of vitamin D, especially fatty fish
Contains essential minerals like selenium, zinc, and iodine
May reduce risk of autoimmune diseases
Can improve sleep quality
Supports eye health and may reduce risk of age-related macular degeneration
May lower risk of type 2 diabetes
Beneficial for fetal development during pregnancy
Can help in weight management due to its protein content and low calories
May reduce inflammation in the body
Supports bone health due to its vitamin D content
Can improve skin health and appearanceRemember that the specific benefits can vary depending on the type of fish and how it’s prepared.
Pregnant women (due to potential mercury content in some fish)
Breastfeeding mothers (for the same reason as pregnant women)
Young children (their developing nervous systems are more susceptible to mercury)
People with fish allergies
Individuals with a history of severe allergic reactions to fish or shellfish
Those following a strict vegetarian or vegan diet
People with gout (certain fish are high in purines)
Individuals on specific medications that interact with compounds in fish (e.g., MAO inhibitors)
Those with compromised immune systems (due to risk of foodborne illness from raw or undercooked fish)
People with certain metabolic disorders that affect protein processing
Individuals with severe iodine sensitivities (as some fish are high in iodine)
Those advised by their healthcare provider to avoid fish for specific health reasonsRemember that many of these restrictions apply to specific types of fish or preparations, and not necessarily all fish. Always consult with a healthcare provider for personalized advice.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
Asked Questions 1
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.