Is Four Roses Gluten Free?
Yes, Four Roses bourbon is generally considered gluten-free. Like most distilled spirits, the distillation process removes gluten proteins, making the final product safe for those with gluten sensitivities or celiac disease to consume.

May reduce the risk of heart disease (when consumed in moderation)
May lower the risk of ischemic stroke
Potentially increases HDL (good) cholesterol levels
May reduce the risk of gallstones
May lower the risk of diabetes (in moderate drinkers)It’s important to note that:1. These potential benefits are associated with moderate alcohol consumption in general, not specifically with Four Roses bourbon.2. The risks of alcohol consumption often outweigh any potential benefits.3. Health organizations do not recommend starting to drink alcohol for any potential health benefits.4. Excessive alcohol consumption can lead to numerous health problems and addiction.If you’re looking for health benefits from a specific food or drink, it would be better to focus on fruits, vegetables, whole grains, and other nutrient-rich foods recommended by health professionals.
Pregnant women or those trying to conceive
Individuals under the legal drinking age (21 in the United States)
People with alcohol use disorder or a history of alcohol addiction
Individuals taking medications that interact negatively with alcohol
Those with certain medical conditions, such as liver disease or pancreatitis
People operating vehicles or heavy machinery
Individuals with a history of alcohol-related behavioral issues
Those who are alcohol-intolerant or have alcohol allergies
People in recovery from alcohol addiction
Individuals with certain mental health conditions that may be exacerbated by alcohol use
Those on certain diets or with specific religious beliefs that prohibit alcohol consumption
People who are the designated driver for others
Individuals participating in activities that require full attention and coordination
Those who are immunocompromised or undergoing certain medical treatmentsIt’s important to note that this list is not exhaustive, and individuals should consult with their healthcare provider if they have any concerns about alcohol consumption.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
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Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.