Is Frank’S Red Hot Gluten Free?
Yes, Frank’s RedHot sauce is gluten-free. The company confirms on their website that all varieties of their hot sauce are free from gluten-containing ingredients.

Low in calories: Frank’s RedHot is very low in calories, making it a good option for those watching their calorie intake.
No fat or cholesterol: The sauce contains no fat or cholesterol, which can be beneficial for heart health.
Contains capsaicin: The active compound in chili peppers may help boost metabolism and reduce appetite.
Vitamin C: The sauce contains some vitamin C from the peppers, which supports immune function.
Antioxidants: Cayenne peppers contain antioxidants that may help fight free radicals in the body.
May reduce inflammation: Some studies suggest capsaicin might have anti-inflammatory properties.
Flavor enhancer: It can add flavor to foods without adding significant calories, potentially helping with portion control.
Vinegar content: The vinegar in the sauce may have some probiotic benefits for gut health.
Potential pain relief: Capsaicin is sometimes used topically for pain relief, though this isn’t directly related to consuming the sauce.Remember that while these potential benefits exist, hot sauce should be consumed in moderation as part of a balanced diet. Excessive consumption may lead to digestive discomfort for some individuals.
Those with severe acid reflux or GERD (Gastroesophageal reflux disease)
Individuals with peptic ulcers or other gastrointestinal sensitivities
People with known allergies to any of the ingredients (e.g., cayenne peppers, vinegar)
Those on a low-sodium diet, as hot sauces can be high in sodium
Individuals with irritable bowel syndrome (IBS) who find spicy foods trigger symptoms
People with hemorrhoids or anal fissures, as spicy foods can irritate these conditions
Those with a history of heartburn who find spicy foods exacerbate the condition
Individuals taking certain medications that may interact with spicy foods
People with oral sores, cuts, or inflammation in the mouth
Those with a low tolerance for spicy foods
Infants and very young children, due to the strong flavor and potential digestive issues
Individuals recovering from certain gastrointestinal surgeries or procedures
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What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
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This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
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Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently Asked Questions
Our Expert
Drs. Ilse van Asperen
Drs. Ilse van Asperen is a medical doctor specialising in orthomolecular therapy and nutritional coaching. With a background in public and clinical health research and management, she focuses on addressing the root causes of health issues through diet, gut health, and stress reduction. As a professional editor for Little Helpers, she reviews all gluten-free content to ensure accuracy, safety, and scientific credibility. More about me
Our Sources
The information on this page is based on reputable health and nutrition organisations, ensuring accuracy and reliability for anyone following a gluten-free diet. For further details, see the sources below.
Sources
Experiences of our customers
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.