Is Grain Vinegar Gluten Free?
Generally, grain vinegar is considered gluten-free because the distillation process removes gluten proteins. However, some people with celiac disease or severe gluten sensitivity may still react to trace amounts that could potentially remain, so it’s best to choose vinegars labeled as gluten-free or made from gluten-free sources if you have concerns.

Aids in digestion: Grain vinegar can help stimulate digestive enzymes and improve overall gut health.
Blood sugar control: It may help lower blood sugar levels, particularly when consumed with high-carbohydrate meals.
Weight management: Some studies suggest that vinegar consumption may increase feelings of fullness, potentially leading to reduced calorie intake.
Antimicrobial properties: Grain vinegar has natural antimicrobial effects, which can help fight harmful bacteria.
Heart health: It may help lower cholesterol levels and reduce the risk of heart disease.
Blood pressure regulation: Some research indicates that vinegar consumption might help lower blood pressure.
Antioxidant effects: Grain vinegar contains antioxidants that can help protect cells from damage caused by free radicals.
Nutrient absorption: It may enhance the body’s ability to absorb certain nutrients from food.
Potential cancer-fighting properties: Some studies suggest that vinegar might have anti-tumor effects, though more research is needed.
Skin health: When applied topically, diluted vinegar may help with certain skin conditions due to its antimicrobial properties.
Energy boost: The amino acids in grain vinegar may help combat fatigue.Remember that while these benefits have been observed in various studies, more research is often needed to fully understand the extent of vinegar’s health effects. Always consult with a healthcare professional before making significant changes to your diet.
People with celiac disease or gluten sensitivity, as some grain vinegars may contain gluten
Individuals with allergies to specific grains used in the vinegar production (e.g., wheat, corn, or rice)
Those following a low-histamine diet, as vinegar is high in histamines
People with severe acid reflux or GERD, as vinegar’s acidity may exacerbate symptoms
Individuals with gastroparesis, as vinegar can delay stomach emptying
Those with certain digestive disorders like IBS, who may experience increased symptoms
People taking certain medications that interact with vinegar, such as diuretics or insulin
Individuals with tooth enamel erosion, as vinegar’s acidity can further damage teeth
Those with potassium-restricted diets, as some vinegars contain small amounts of potassium
People with yeast sensitivities or candida overgrowth, as vinegar is a fermented product
Individuals following specific religious or cultural dietary restrictions that prohibit vinegar consumptionAlways consult with a healthcare professional or registered dietitian before making significant changes to your diet, especially if you have underlying health conditions.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
Asked Questions 1
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.