Is Grenadine Gluten Free?
Grenadine, a sweet syrup commonly used in cocktails and other beverages, is typically gluten-free as it is primarily made from pomegranate juice, sugar, and water. However, it’s always best to check the specific brand’s ingredients list or contact the manufacturer directly to confirm, as some less common varieties might contain additives or flavorings that could potentially contain gluten.

Rich in antioxidants: Pomegranate-based grenadine contains polyphenols, which are powerful antioxidants that can help protect cells from damage.
May have anti-inflammatory properties: The antioxidants in pomegranate can help reduce inflammation in the body.
Potential heart health benefits: Some studies suggest that pomegranate juice may help lower blood pressure and reduce the risk of heart disease.
May support urinary health: Pomegranate has been associated with improved urinary tract health and may help prevent urinary tract infections.
Possible immune system support: The vitamin C content in pomegranate can contribute to a stronger immune system.
Potential cognitive benefits: Some research indicates that pomegranate may help improve memory and cognitive function.
May have anti-cancer properties: Certain compounds in pomegranate have shown potential in inhibiting cancer cell growth in laboratory studies.
Dental health: Pomegranate may help reduce bacteria that cause dental plaque.
Skin health: The antioxidants in pomegranate could contribute to healthier skin and may help protect against UV damage.It’s important to note that many commercial grenadine syrups are made with artificial flavors and high amounts of sugar, which can negate some of these health benefits. For maximum health benefits, look for natural, pomegranate-based grenadine or consider making your own at home.
People with diabetes or those monitoring their blood sugar levels, as grenadine is high in sugar content
Individuals on a low-sugar or low-calorie diet
Those with fructose intolerance or malabsorption, as grenadine often contains high fructose corn syrup
People with allergies to pomegranate or other fruits used in grenadine production
Individuals with sensitivities to food dyes or artificial colors, as some grenadine brands contain these additives
Those taking certain medications that may interact with grapefruit (if the grenadine contains grapefruit)
People with a history of kidney stones, as pomegranate (a common ingredient in grenadine) may increase the risk
Individuals with dental concerns, due to the high sugar content and acidity of grenadine
Those following a kosher or halal diet should check the ingredients and production methods
Pregnant or breastfeeding women should consult their healthcare provider before consuming products containing grenadineRemember that moderation is key, and it’s always best to consult with a healthcare professional if you have any specific health concerns or conditions.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently Asked Questions
Our Expert
Drs. Ilse van Asperen
Drs. Ilse van Asperen is a medical doctor specialising in orthomolecular therapy and nutritional coaching. With a background in public and clinical health research and management, she focuses on addressing the root causes of health issues through diet, gut health, and stress reduction. As a professional editor for Little Helpers, she reviews all gluten-free content to ensure accuracy, safety, and scientific credibility. More about me
Our Sources
The information on this page is based on reputable health and nutrition organisations, ensuring accuracy and reliability for anyone following a gluten-free diet. For further details, see the sources below.
Sources
Experiences of our customers
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.