Is Horseradish Gluten Free?
Horseradish root itself is naturally gluten-free. However, some prepared horseradish products may contain gluten-containing additives or be processed in facilities that also handle gluten, so it’s important to check labels carefully if you have celiac disease or gluten sensitivity.

Rich in antioxidants, which help protect cells from damage
May have anti-cancer properties, particularly for colon cancer
Contains compounds that can help fight bacterial infections
Supports respiratory health by clearing sinuses and reducing congestion
May aid in digestion by stimulating the production of digestive enzymes
Has diuretic properties, which can help flush toxins from the body
Contains glucosinolates, which may have anti-inflammatory effects
Low in calories but high in flavor, making it a good option for weight management
Provides vitamin C, which supports immune system function
Contains calcium and potassium, important for bone and heart health
May help lower blood pressure due to its potassium content
Has potential antibiotic properties that can help fight harmful bacteria
Can stimulate appetite, which may be beneficial for those with reduced hunger
May help relieve muscle and joint pain when applied topicallyRemember that while horseradish has many potential health benefits, it should be consumed in moderation as part of a balanced diet. Some individuals may be sensitive to its strong flavor or experience digestive discomfort if consumed in large amounts.
Infants and young children, due to its strong flavor and potential digestive irritation
Pregnant women, as large amounts may stimulate the uterus
Breastfeeding mothers, as it may affect the taste of breast milk
People with gastrointestinal ulcers or inflammatory bowel diseases like Crohn’s or ulcerative colitis
Individuals with kidney problems, as horseradish is high in potassium
Those with thyroid disorders, as horseradish may interfere with thyroid function
People taking certain medications, such as blood thinners or ACE inhibitors (consult a doctor)
Individuals with a known allergy to horseradish or other plants in the Brassicaceae family (e.g., mustard, wasabi)
Those with gastroesophageal reflux disease (GERD) or chronic heartburn
People recovering from stomach or intestinal surgery
Individuals with a history of kidney stones
Those with sensitive digestive systems or prone to stomach upsetAlways consult a healthcare professional if you have concerns about consuming horseradish, especially if you have any medical conditions or are taking medications.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently Asked Questions
Our Expert
Drs. Ilse van Asperen
Drs. Ilse van Asperen is a medical doctor specialising in orthomolecular therapy and nutritional coaching. With a background in public and clinical health research and management, she focuses on addressing the root causes of health issues through diet, gut health, and stress reduction. As a professional editor for Little Helpers, she reviews all gluten-free content to ensure accuracy, safety, and scientific credibility. More about me
Our Sources
The information on this page is based on reputable health and nutrition organisations, ensuring accuracy and reliability for anyone following a gluten-free diet. For further details, see the sources below.
Sources
Experiences of our customers
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.