Is Juice Gluten Free?
Generally speaking, pure fruit juice is naturally gluten-free as it does not contain any wheat, barley, rye, or their derivatives. However, it’s important to check labels carefully, especially for flavored or mixed juices, as some may contain gluten-containing additives or be processed in facilities that handle gluten products.

Rich source of vitamins and minerals
Provides antioxidants to fight free radicals
Can boost hydration
May improve digestion
Supports immune system function
Can help increase energy levels
May aid in weight management (when consumed in moderation)
Provides easily digestible nutrients
Can contribute to daily fruit and vegetable intake
May help reduce inflammation in the body
Can support heart health (especially with certain fruits and vegetables)
May improve skin health
Can aid in detoxification processes
Potential to lower blood pressure (with certain juices)
May help regulate blood sugar levels (depending on the type of juice)
Can support bone health (with calcium-rich juices)
Potential to improve cognitive function
May help reduce the risk of certain cancers (due to antioxidants)Remember that while juice can offer health benefits, it’s important to consume it in moderation as part of a balanced diet, as some juices can be high in sugar and calories.
Individuals with diabetes or pre-diabetes, due to the high sugar content in most juices
People trying to lose weight or manage their calorie intake
Those with acid reflux or GERD, especially for citrus juices
Individuals with fructose malabsorption or intolerance
People with certain gastrointestinal disorders, such as IBS, who may be sensitive to fruit sugars
Young children, as excessive juice consumption can lead to tooth decay and poor nutrition
Those taking certain medications that may interact with compounds in grapefruit juice
Individuals with a history of kidney stones, particularly for juices high in oxalates
People with blood sugar regulation issues or hypoglycemia
Those with certain liver conditions, who may need to limit fructose intake
Individuals following a low-carb or ketogenic diet
People with allergies or sensitivities to specific fruits or ingredients in juicesRemember that these are general guidelines, and it’s always best to consult with a healthcare professional for personalized advice based on individual health conditions and needs.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently Asked Questions
Our Expert
Drs. Ilse van Asperen
Drs. Ilse van Asperen is a medical doctor specialising in orthomolecular therapy and nutritional coaching. With a background in public and clinical health research and management, she focuses on addressing the root causes of health issues through diet, gut health, and stress reduction. As a professional editor for Little Helpers, she reviews all gluten-free content to ensure accuracy, safety, and scientific credibility. More about me
Our Sources
The information on this page is based on reputable health and nutrition organisations, ensuring accuracy and reliability for anyone following a gluten-free diet. For further details, see the sources below.
Sources
Experiences of our customers
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.