Most Manwich brand sloppy joe sauces are gluten-free, as they do not contain wheat, barley, or rye ingredients. However, it’s always best to check the specific product label for the most up-to-date information, as ingredients and manufacturing processes can change over time.

Contains tomatoes, which are a source of lycopene, an antioxidant
Provides some vegetable content in the form of tomatoes and onions
Can be a convenient way to add flavor to lean ground meats
May encourage consumption of whole grain buns if served as a sandwich
Can be combined with additional vegetables to increase nutritional value
Contains some fiber from the vegetable ingredients
Provides a small amount of vitamin C and vitamin A
Low in fat when used with lean ground meat
Can be part of a balanced meal when paired with healthy sidesIt’s important to note that Manwich is also high in sodium and contains added sugars, so it should be consumed in moderation as part of a balanced diet. For optimal health benefits, consider making homemade sloppy joe sauce using fresh ingredients and controlling the salt and sugar content.
Individuals with tomato allergies, as tomatoes are a primary ingredient
People with high blood pressure, due to its sodium content
Those following a low-sodium diet
Individuals with celiac disease or gluten sensitivity (unless using a gluten-free version)
People with sugar sensitivities or diabetes, due to its sugar content
Vegetarians and vegans (unless using a plant-based meat substitute)
Those avoiding processed foods
Individuals with certain food additive sensitivities (e.g., to preservatives or artificial flavors)
People following a low-carb or ketogenic diet
Those with sensitivities to onions or garlic, which are common ingredients
Individuals trying to avoid high fructose corn syrup, which is present in some varieties
People with specific religious or cultural dietary restrictions that prohibit certain ingredientsRemember that ingredient lists can vary between different Manwich products, so it’s always best to check the label for specific concerns.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
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Relief from Gluten Sensitivity
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This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
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Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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