Marsala wine, like most wines, is naturally gluten-free as it is made from grapes and does not contain any gluten-containing ingredients. However, it’s always advisable to check the label or contact the manufacturer for specific products, especially if you have severe gluten sensitivities, as there could be rare instances of cross-contamination or the addition of gluten-containing additives in some flavored or specialty versions.

Rich in antioxidants: Contains polyphenols that may help protect cells from damage caused by free radicals
May support heart health: Moderate consumption may help increase HDL (good) cholesterol levels
Potential anti-inflammatory properties: May help reduce inflammation in the body
Could aid digestion: Some believe it can stimulate appetite and aid in digestion when consumed before or after meals
May have cognitive benefits: Moderate wine consumption has been linked to potential improvements in cognitive function in some studies
Possible blood sugar regulation: Some research suggests it may help regulate blood sugar levels
Source of certain nutrients: Contains small amounts of minerals like potassium, calcium, and magnesium
Potential stress reduction: Moderate consumption may help reduce stress and promote relaxation
May have antimicrobial properties: Some compounds in wine have shown antimicrobial effects in laboratory studies
Possible longevity benefits: Moderate wine consumption has been associated with increased lifespan in some population studiesIt’s important to note that these benefits are associated with moderate consumption, and excessive alcohol intake can lead to serious health problems. Always consult with a healthcare professional regarding alcohol consumption and its effects on your individual health.
Pregnant women: Alcohol consumption during pregnancy can lead to fetal alcohol spectrum disorders and other developmental issues.
Individuals under the legal drinking age: The legal drinking age varies by country but is typically 18 or 21 years old.
People with alcohol use disorder or those in recovery from alcoholism: Consuming any alcoholic beverage can trigger relapse.
Individuals taking certain medications: Some medications can interact negatively with alcohol, including antibiotics, antidepressants, and blood thinners.
People with liver disease or other liver problems: Alcohol can further damage the liver in these individuals.
Those with a history of pancreatitis: Alcohol consumption can trigger or worsen pancreatitis.
Individuals with certain medical conditions: Such as uncontrolled high blood pressure, heart disease, or diabetes.
People operating heavy machinery or vehicles: Alcohol impairs judgment and reaction time.
Individuals with alcohol intolerance or allergies: Some people may experience adverse reactions to alcohol or its ingredients.
Those following certain religious or cultural practices that prohibit alcohol consumption.
People with a family history of alcoholism: They may be at higher risk for developing alcohol use disorder.Always consult with a healthcare professional for personalized advice regarding alcohol consumption.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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