Midol, a brand of over-the-counter medication used for menstrual symptoms, is generally considered gluten-free. However, it’s always best to check the specific product packaging or contact the manufacturer directly for the most up-to-date and accurate information about gluten content, as formulations can change over time.

Pain relief: Helps reduce menstrual cramps and general body aches
Headache relief: Can alleviate headaches often associated with menstruation
Bloating reduction: Contains a diuretic to help reduce water retention and bloating
Mood improvement: May help with irritability and mood swings related to PMS
Fever reduction: Can lower fever if present during menstruation
Backache relief: Assists in reducing lower back pain often experienced during periods
Fatigue reduction: Some formulations contain caffeine, which can help combat fatigue
Muscle ache relief: Helps alleviate general muscle soreness
Multipurpose relief: Can be used for other types of pain, such as toothaches or minor arthritis pain
Convenient: Provides relief for multiple symptoms in one medicationIt’s important to note that the specific benefits may vary depending on the particular Midol formulation, as there are different types available. Always follow the recommended dosage and consult with a healthcare professional if you have any concerns or underlying health conditions.
Those with known allergies or hypersensitivity to any of its ingredients (acetaminophen, caffeine, or pyrilamine maleate)
People with liver disease or a history of liver problems
Individuals with a history of stomach ulcers or bleeding disorders
Those taking blood thinners or anticoagulants
People with phenylketonuria (PKU), as some Midol products contain phenylalanine
Individuals with glaucoma
Those with severe high blood pressure or heart disease
People with thyroid problems
Individuals taking monoamine oxidase inhibitors (MAOIs)
Pregnant women, especially in the third trimester
Breastfeeding mothers, unless advised by a healthcare provider
Children under 12 years old, unless recommended by a pediatrician
People with a history of drug or alcohol abuse
Those with kidney problemsAlways consult with a healthcare professional before using any medication, especially if you have pre-existing medical conditions or are taking other medications.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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