Motrin, which contains ibuprofen as its active ingredient, is generally considered gluten-free. However, it’s always best to check the specific product label or consult with the manufacturer for the most up-to-date information, as formulations can change over time.

Pain relief: Effective for reducing various types of pain, including headaches, menstrual cramps, toothaches, and muscle aches
Fever reduction: Helps lower body temperature in cases of fever
Anti-inflammatory properties: Reduces inflammation in the body, which can help with conditions like arthritis
Menstrual symptom relief: Alleviates menstrual cramps and associated discomfort
Migraine treatment: Can be effective in treating migraine headaches
Joint pain relief: Helps reduce pain and stiffness associated with osteoarthritis and rheumatoid arthritis
Back pain management: Provides relief for acute lower back pain
Post-surgery pain relief: Often used to manage pain following surgical procedures
Sports injury treatment: Helps reduce pain and swelling from minor sports-related injuries
Dental pain relief: Effective for managing pain after dental procedures or toothaches
Tendinitis relief: Reduces pain and inflammation associated with tendinitis
Bursitis treatment: Helps alleviate pain and swelling in bursitis casesIt’s important to note that while Motrin offers these benefits, it should be used as directed and under the guidance of a healthcare professional, especially for long-term use or pre-existing medical conditions.
Individuals with a known allergy or hypersensitivity to ibuprofen or other NSAIDs
People with a history of asthma attacks, hives, or other allergic reactions after taking aspirin or other NSAIDs
Those with active or recurrent stomach ulcers or gastrointestinal bleeding
Patients who have recently had heart bypass surgery (coronary artery bypass graft or CABG)
Individuals in the last trimester of pregnancy
People with severe liver disease or liver failure
Those with severe kidney disease or kidney failure
Individuals with heart failure or at high risk for heart-related problems
People taking certain medications that may interact with Motrin, such as blood thinners or other NSAIDs
Those with a history of stroke or at high risk for stroke
Individuals with uncontrolled high blood pressure
People with certain bleeding disorders
Those who consume large amounts of alcohol regularlyAlways consult with a healthcare professional before taking Motrin, especially if you have any pre-existing medical conditions or are taking other medications.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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