NyQuil’s original liquid formula is generally considered gluten-free, as it does not contain any ingredients derived from wheat, barley, or rye. However, it’s always best to check the specific product label or consult with the manufacturer, as formulations can change and some NyQuil variants or generic versions might contain gluten-derived ingredients.

Relieves nasal congestion and sinus pressure
Reduces coughing and soothes sore throat
Alleviates body aches and headaches
Lowers fever
Promotes sleep and rest, which can aid recovery
Combines multiple symptom relief in one medication
Provides temporary relief from nighttime cold and flu symptoms
May help prevent sleep disruptions caused by symptoms
Can improve overall comfort during illnessIt’s important to note that NyQuil should only be used as directed and for short-term symptom relief. It is not a cure for colds or flu, and overuse or misuse can lead to potential side effects or health risks. Always consult with a healthcare professional if symptoms persist or worsen.
Children under 12 years old
Pregnant women
Breastfeeding mothers
People with liver disease or impaired liver function
Individuals with a history of alcoholism
Those taking MAO inhibitors (a type of antidepressant)
People with narrow-angle glaucoma
Individuals with stenosing peptic ulcers
Those with symptomatic prostatic hypertrophy
People with bladder neck obstruction
Individuals with known hypersensitivity to any of the ingredients
Those with severe hypertension or coronary artery disease
People taking other medications containing acetaminophen
Individuals with respiratory depression
Those with a history of drug abuse
People taking sedatives, tranquilizers, or other CNS depressants
Individuals with chronic obstructive pulmonary disease (COPD)Always consult with a healthcare professional before taking NyQuil if you have any concerns or medical conditions.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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