Is Orange Juice Gluten Free?
Yes, pure orange juice is naturally gluten-free as it is made solely from oranges, which do not contain gluten. However, it’s always important to check the label of any packaged orange juice to ensure no gluten-containing additives or flavorings have been included, especially in the case of flavored or fortified orange juice products.

Rich in Vitamin C: Boosts immune system and acts as an antioxidant
Good source of folate: Important for cell growth and DNA synthesis
Contains potassium: Helps regulate blood pressure and supports heart health
Provides flavonoids: May have anti-inflammatory and antioxidant properties
Hydrating: Helps maintain proper fluid balance in the body
May improve brain function: Due to its antioxidant content
Supports skin health: Vitamin C aids in collagen production
Contains hesperidin: May help lower cholesterol levels
Provides some calcium: Important for bone health
May enhance iron absorption: Vitamin C helps the body absorb iron from other foods
Contains citric acid: May help prevent kidney stones
Offers some B vitamins: Important for energy metabolism
May have anti-cancer properties: Due to its antioxidant content
Supports eye health: Contains carotenoids like beta-cryptoxanthinRemember, while orange juice has many benefits, it’s also high in sugar and calories, so it should be consumed in moderation as part of a balanced diet.
People with gastroesophageal reflux disease (GERD) or acid reflux, as the acidity can worsen symptoms
Individuals with citrus allergies or sensitivities
Those with diabetes or at risk for diabetes, due to the high sugar content
People trying to lose weight, as fruit juices are calorie-dense
Individuals taking certain medications that interact with grapefruit juice (some orange juices contain small amounts of grapefruit juice)
Those with kidney stones, as the high levels of oxalates can contribute to stone formation
People with irritable bowel syndrome (IBS) who are sensitive to FODMAPs
Individuals with teeth sensitivity or those concerned about tooth enamel erosion
Those with potassium-restricted diets, as orange juice is high in potassium
People with certain digestive disorders that are aggravated by acidic foods
Individuals prone to migraines, as citrus can be a trigger for some
Those taking blood-thinning medications, as the vitamin K in orange juice can interfere with their effectivenessAlways consult with a healthcare professional for personalized advice regarding dietary restrictions or concerns.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
Asked Questions 1
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.