Oregano is naturally gluten-free as it is an herb derived from a plant in the mint family. However, as with any spice or herb, there is a small risk of cross-contamination during processing or packaging, so those with severe gluten sensitivities should always check the label or contact the manufacturer to ensure the specific product is certified gluten-free.

Rich in antioxidants, which help protect cells from damage
Anti-inflammatory properties that may reduce chronic inflammation
Antibacterial and antimicrobial effects, potentially fighting harmful bacteria
May help fight viral infections
Potential to lower cholesterol levels
Possible anti-cancer properties, particularly against colon and breast cancer cells
May aid in digestion and reduce bloating
Potential to alleviate menstrual cramps
Rich in vitamins and minerals, including vitamin K, iron, and manganese
May help regulate blood sugar levels
Possible benefits for respiratory health, including easing coughs and congestion
Potential to boost the immune system
May have mild pain-relieving properties
Could help in treating skin conditions when applied topically
Possible mood-enhancing effects due to its carvacrol contentRemember that while oregano has many potential benefits, more research is needed to fully understand its effects, and it should not replace professional medical advice or treatment.
Pregnant women: In large medicinal doses, oregano may stimulate uterine contractions and potentially increase the risk of miscarriage.
Breastfeeding mothers: There’s not enough reliable information about the safety of using oregano in medicinal amounts while breastfeeding.
People with bleeding disorders: Oregano might slow blood clotting and increase the risk of bleeding in people with bleeding disorders.
Individuals scheduled for surgery: Due to its potential effect on blood clotting, oregano should be avoided at least two weeks before a scheduled surgery.
People with allergies to plants in the Lamiaceae family: Those allergic to basil, lavender, mint, or sage may also be allergic to oregano.
Diabetics: Oregano might lower blood sugar levels, potentially interfering with diabetes medications.
People with iron deficiency: Oregano may decrease iron absorption when consumed in large amounts.
Individuals taking lithium: Oregano might have a diuretic effect, potentially affecting how the body processes lithium.
Those with certain hormone-sensitive conditions: Oregano might have estrogen-like effects, which could be a concern for people with hormone-sensitive conditions.Always consult with a healthcare provider before using oregano in medicinal amounts, especially if you have any health conditions or are taking medications.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
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Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.