Yes, the Paleo diet is generally considered to be gluten-free. This is because the Paleo diet excludes grains, including wheat, barley, and rye, which are the primary sources of gluten in most diets.

Weight loss and improved body composition
Increased insulin sensitivity and better blood sugar control
Reduced inflammation in the body
Improved heart health and lower risk of cardiovascular disease
Better digestive health and reduced gastrointestinal issues
Increased nutrient density in the diet
Improved satiety and reduced hunger cravings
Potential reduction in allergies and food sensitivities
Enhanced athletic performance and recovery
Better sleep quality
Clearer skin and potential reduction in acne
Increased energy levels and improved mood
Reduced risk of autoimmune diseases
Lower risk of certain types of cancer
Improved brain function and reduced risk of neurodegenerative diseasesIt’s important to note that while many people report these benefits, scientific evidence varies, and the diet may not be suitable for everyone. Always consult with a healthcare professional before making significant changes to your diet.
People with kidney disease or reduced kidney function, due to the diet’s high protein content
Individuals with osteoporosis or at risk for bone loss, as the diet may limit calcium intake
Those with a history of eating disorders, as the restrictive nature of the diet could trigger disordered eating patterns
People with diabetes who are insulin-dependent, as the diet may affect blood sugar levels
Vegetarians and vegans, as the diet heavily relies on animal products
Individuals with high cholesterol, as the diet can be high in saturated fats
People with a history of heart disease, due to the potential increase in saturated fat intake
Those with digestive issues like irritable bowel syndrome (IBS), as the high fiber content may exacerbate symptoms
Endurance athletes or people with high energy needs, as the diet may not provide sufficient carbohydrates
Individuals with a history of diverticulitis, as the high fiber content may cause complications
Pregnant or breastfeeding women, who may require more varied nutrition
People on a tight budget, as the diet can be expensive due to its emphasis on high-quality meats and organic produce
Those with certain food allergies or intolerances that conflict with Paleo-approved foodsAlways consult with a healthcare professional or registered dietitian before starting any new diet, especially if you have pre-existing health conditions or concerns.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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