The Paleo diet is inherently gluten-free as it excludes all grains, including wheat, barley, and rye, which are the primary sources of gluten in most diets. However, it’s important to note that while Paleo is gluten-free, not all gluten-free foods are necessarily Paleo-compliant, as the Paleo diet has additional restrictions beyond just avoiding gluten.

Weight loss and improved body composition
Increased insulin sensitivity and better blood sugar control
Reduced inflammation in the body
Improved heart health and lower risk of cardiovascular disease
Better digestive health due to increased fiber intake
Higher protein intake, which can support muscle growth and maintenance
Increased consumption of healthy fats, including omega-3 fatty acids
Improved satiety and reduced hunger due to higher protein and fat intake
Potential reduction in allergies and food sensitivities
Increased intake of vitamins, minerals, and antioxidants from whole foods
Better sleep quality
Increased energy levels throughout the day
Potential improvement in autoimmune conditions
Reduced risk of certain types of cancer
Better skin health and appearance
Improved brain function and reduced risk of neurodegenerative diseases
Enhanced athletic performance and recoveryIt’s important to note that while many people report these benefits, scientific research on the long-term effects of the Paleo diet is still ongoing, and individual results may vary.
Individuals with kidney disease or reduced kidney function
People with osteoporosis or at high risk for bone loss
Those with a history of eating disorders
Individuals with high cholesterol levels, particularly LDL cholesterol
People with diabetes who are insulin-dependent
Vegetarians or vegans, as the diet heavily relies on animal products
Those with digestive issues that may be exacerbated by high fat intake
Individuals with a history of cardiovascular disease
Pregnant or breastfeeding women, unless under close medical supervision
People with specific nutrient deficiencies, particularly in calcium or vitamin D
Athletes or highly active individuals who require high amounts of carbohydrates
Those on certain medications that may interact with a high-protein, low-carb diet
Individuals with a history of gout or high uric acid levels
People with limited financial resources, as the diet can be expensive
Those who struggle with dietary restrictions or have difficulty following strict eating plansIt’s always advisable to consult with a healthcare professional or registered dietitian before making significant changes to your diet, especially if you have pre-existing health conditions.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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