Most traditional pasta sauces are naturally gluten-free as they are typically made from ingredients like tomatoes, herbs, and vegetables that do not contain gluten. However, it’s always important to check the label of store-bought sauces, as some may contain gluten-containing additives or thickeners, or be produced in facilities that process gluten-containing products.

Rich in lycopene, a powerful antioxidant that may reduce the risk of certain cancers and heart disease
Good source of vitamins A and C, which support immune function and skin health
Contains potassium, which helps regulate blood pressure and supports heart health
Provides dietary fiber, aiding in digestion and promoting feelings of fullness
Low in calories when made with simple, natural ingredients
Contains beta-carotene, which supports eye health and can be converted to vitamin A in the body
Offers anti-inflammatory properties due to various compounds found in tomatoes
May help reduce the risk of stroke due to its high lycopene content
Can contribute to bone health due to the presence of vitamin K and calcium in some recipes
Garlic and herbs often used in pasta sauces have additional health benefits, including antioxidant and antimicrobial properties
Can increase the absorption of certain nutrients when paired with other foods, particularly those containing healthy fatsRemember that the health benefits can vary depending on the specific ingredients and preparation method of the pasta sauce.
People with tomato allergies: Most pasta sauces are tomato-based and could trigger allergic reactions.
Individuals with acid reflux or GERD: Tomato-based sauces are acidic and may worsen symptoms.
Those with irritable bowel syndrome (IBS): Some may find that tomato-based sauces trigger symptoms.
People on low-sodium diets: Many commercial pasta sauces are high in sodium.
Individuals with nightshade sensitivities: Tomatoes are part of the nightshade family and may cause issues for some.
Those with histamine intolerance: Tomatoes are high in histamines, which can cause problems for sensitive individuals.
People with specific food intolerances: Some sauces may contain ingredients like garlic, onions, or dairy that some individuals need to avoid.
Individuals on low-carb or ketogenic diets: Pasta sauce often contains added sugars and carbohydrates.
Those with certain gastrointestinal conditions: Some may need to avoid acidic or spicy foods, including certain pasta sauces.
People with specific medication interactions: Some medications may interact with compounds in tomatoes or other ingredients in pasta sauce.Always consult with a healthcare professional for personalized dietary advice.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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