Patron Tequila is gluten-free. This is because tequila is made from the blue agave plant, which does not contain gluten, and the production process does not introduce any gluten-containing ingredients.

Aids Digestion: Patrón Tequila can stimulate the metabolism and aid digestion. Many cultures enjoy a shot of tequila after meals to help soothe the digestive process, thanks to compounds found in the agave plant from which it is made.
Weight Management: The agavins in tequila are a type of sugar that does not raise blood sugar levels.
Probiotic Properties: Patrón contains prebiotics derived from agave, which can promote the growth of healthy gut bacteria.
Low Glycemic Index: Patrón Tequila has a lower glycemic index compared to many other alcoholic beverages, making it a better option for those looking to manage blood sugar levels .
Individuals under the legal drinking age (21 in the United States)
Pregnant women or those trying to conceive
People with alcohol use disorders or those in recovery from alcohol addiction
Individuals taking medications that interact negatively with alcohol
Those with liver disease or other health conditions affected by alcohol consumption
People who are operating vehicles or machinery
Individuals with a history of alcohol-related behavioral issues
Those who are allergic to agave or other ingredients in tequila
People who need to maintain alertness for work or other responsibilities
Individuals with religious or personal beliefs that prohibit alcohol consumption
Those on certain diets that restrict alcohol intake
People with a low tolerance for alcohol or who experience severe hangoversRemember, even for those not in these categories, moderation is key when consuming any alcoholic beverage.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
Asked Questions