Paxlovid, the antiviral medication used to treat COVID-19, does not contain gluten as an ingredient. However, as with many medications, individuals with celiac disease or gluten sensitivity should consult their healthcare provider or pharmacist to confirm the gluten-free status of their specific prescription, as manufacturing processes can sometimes introduce trace amounts of gluten.

Reduces risk of hospitalization and death: Paxlovid significantly lowers the risk of severe COVID-19 outcomes in high-risk patients.
Shortens illness duration: It can help reduce the length of time a person experiences COVID-19 symptoms.
Decreases viral load: Paxlovid works by inhibiting the SARS-CoV-2 virus from replicating, thus lowering the amount of virus in the body.
Prevents progression to severe disease: It can help keep mild to moderate cases from developing into more serious conditions.
Effective against variants: Paxlovid has shown effectiveness against multiple COVID-19 variants.
Oral medication: Being a pill, it’s easier to administer than intravenous treatments and can be taken at home.
Helps preserve hospital capacity: By reducing hospitalizations, it helps maintain healthcare system capacity.
Potential to reduce long COVID risk: While more research is needed, early treatment may help reduce the risk of long-term COVID-19 effects.
Provides treatment option for those who can’t be vaccinated: Offers a therapeutic option for individuals who cannot receive COVID-19 vaccines due to medical reasons.Remember, Paxlovid should only be used under medical supervision and is typically prescribed for individuals at high risk for severe COVID-19.
People with severe kidney disease (eGFR <30 mL/min)
People with severe liver disease
Individuals taking certain medications that interact dangerously with Paxlovid, such as: – Some heart medications (e.g., amiodarone, dronedarone) – Some psychiatric medications (e.g., lurasidone, pimozide) – Some pain medications (e.g., methylergonovine, ergotamine) – Some cancer drugs (e.g., apalutamide) – Some cholesterol-lowering drugs (e.g., lovastatin, simvastatin)
People with known hypersensitivity to nirmatrelvir, ritonavir, or any other components of Paxlovid
Individuals taking medications that are highly dependent on CYP3A for clearance and for which elevated concentrations are associated with serious reactions
People using products containing St. John’s Wort, as it may decrease Paxlovid’s effectiveness
Pregnant women, unless the potential benefit justifies the potential risk to the fetus
Individuals under 12 years of age or weighing less than 40 kg (88 pounds)Always consult with a healthcare provider before starting or stopping any medication, as they can provide personalized advice based on an individual’s specific health situation and medication regimen.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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