Pepcid (famotidine) is generally considered gluten-free, as it does not contain wheat, barley, rye, or other gluten-containing ingredients in its active or inactive components. However, it’s always best to check the specific product label or consult with the manufacturer to confirm, as formulations can sometimes change or vary between different versions of the medication.

Reduces stomach acid production, helping to relieve heartburn and acid indigestion
Treats and prevents gastroesophageal reflux disease (GERD)
Helps heal stomach and duodenal ulcers
Prevents stress ulcers in critically ill patients
Manages symptoms of Zollinger-Ellison syndrome, a condition that causes excess stomach acid production
May help prevent aspiration pneumonia in patients undergoing surgery
Can be used to treat and prevent gastric ulcers caused by nonsteroidal anti-inflammatory drugs (NSAIDs)
Helps relieve symptoms of dyspepsia (indigestion)
May reduce the risk of gastrointestinal bleeding in certain high-risk patients
Can be used to treat certain types of allergic reactions, such as hives, when combined with other antihistamines
May help manage symptoms of eosinophilic esophagitis, an allergic inflammatory condition of the esophagusIt’s important to note that Pepcid should be used as directed by a healthcare professional, as it may have side effects and interactions with other medications.
People with known allergies or hypersensitivity to famotidine or other H2 blockers
Individuals with severe kidney problems or kidney disease
Those with a history of long QT syndrome (a heart rhythm disorder)
Pregnant women, unless specifically advised by a doctor
Breastfeeding mothers, without consulting a healthcare provider
People with liver disease or impaired liver function
Individuals taking certain medications that may interact with Pepcid, such as: – Atazanavir (for HIV treatment) – Dasabuvir (for hepatitis C treatment) – Delavirdine (for HIV treatment) – Erlotinib (for cancer treatment)
Elderly patients, who may be more sensitive to side effects
People with a history of stomach cancer or other gastrointestinal cancers
Individuals with phenylketonuria (PKU), particularly when using the orally disintegrating tablets
Those scheduled for allergy skin tests, as Pepcid may interfere with resultsAlways consult a healthcare professional before starting or stopping any medication, especially if you have pre-existing medical conditions or are taking other drugs.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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