Is Pepper Gluten Free?
Yes, pepper is naturally gluten-free. Both black pepper and other varieties of peppercorns do not contain gluten and are safe for those with celiac disease or gluten sensitivity to consume.

Rich in antioxidants, particularly piperine, which may help prevent cellular damage
May enhance nutrient absorption, especially for selenium, beta-carotene, and curcumin
Potential anti-inflammatory properties that could help reduce chronic inflammation
May improve digestion by stimulating the production of digestive enzymes
Possible metabolism-boosting effects, which could aid in weight management
Contains antimicrobial properties that may help fight certain bacteria
May help relieve nasal congestion and clear sinuses
Potential to improve cognitive function and memory
Possible mood-enhancing effects due to its ability to stimulate the release of endorphins
May help lower blood pressure and improve cardiovascular health
Contains small amounts of essential minerals like manganese, iron, and vitamin K
Potential cancer-fighting properties, though more research is needed
May help manage blood sugar levels, which could be beneficial for people with diabetes
Possible pain-relieving properties, particularly for headaches and arthritisRemember that while these benefits are supported by various studies, more research is often needed to fully understand the extent of pepper’s health effects.
Individuals with gastroesophageal reflux disease (GERD) or acid reflux
People with peptic ulcers or other digestive tract issues
Those with irritable bowel syndrome (IBS)
Individuals with a known allergy or sensitivity to pepper
People recovering from gastrointestinal surgery
Those with hemorrhoids or anal fissures
Individuals with certain skin conditions that may be aggravated by spicy foods
Pregnant women (in large amounts)
Young children, due to their sensitive digestive systems
People taking certain medications that may interact with black pepper (e.g., some blood thinners)
Those with chronic heartburn
Individuals with a history of kidney stones (in large amounts)
People with certain gastrointestinal disorders like Crohn’s disease or ulcerative colitisIt’s important to note that moderate use of pepper is generally safe for most people, and these recommendations are primarily for those who may be more sensitive or have specific health concerns. Always consult with a healthcare professional for personalized advice.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently Asked Questions
Our Expert
Drs. Ilse van Asperen
Drs. Ilse van Asperen is a medical doctor specialising in orthomolecular therapy and nutritional coaching. With a background in public and clinical health research and management, she focuses on addressing the root causes of health issues through diet, gut health, and stress reduction. As a professional editor for Little Helpers, she reviews all gluten-free content to ensure accuracy, safety, and scientific credibility. More about me
Our Sources
The information on this page is based on reputable health and nutrition organisations, ensuring accuracy and reliability for anyone following a gluten-free diet. For further details, see the sources below.
Sources
Experiences of our customers
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.