Is Pistachio Gluten Free?
Yes, pistachios are naturally gluten-free. They are tree nuts and do not contain any wheat, barley, rye, or other gluten-containing grains.

Rich in antioxidants, which help protect cells from damage
Good source of protein, especially for plant-based diets
High in fiber, promoting digestive health and satiety
Contains heart-healthy unsaturated fats
May help lower cholesterol levels
Potentially beneficial for weight management due to their protein and fiber content
Good source of vitamins and minerals, including vitamin B6, thiamine, phosphorus, and copper
May help regulate blood sugar levels
Contains lutein and zeaxanthin, which are beneficial for eye health
May help reduce inflammation in the body
Potentially beneficial for gut health due to their prebiotic properties
Good source of L-arginine, an amino acid that may improve blood flow
May help lower blood pressure
Contains melatonin, which could improve sleep quality
Potentially beneficial for brain health and cognitive functionRemember that while pistachios offer these potential benefits, they should be consumed as part of a balanced diet, and moderation is key due to their calorie density.
People with nut allergies: Pistachios are tree nuts and can cause severe allergic reactions in those with nut allergies.
Individuals with pistachio-specific allergies: Some people may be allergic to pistachios specifically, even if they can tolerate other nuts.
Those on a low-calorie diet: Pistachios are calorie-dense, so people strictly monitoring their calorie intake should consume them in moderation.
Individuals with kidney stones: Pistachios are high in oxalates, which can contribute to kidney stone formation in susceptible individuals.
People with IBS or other digestive issues: The high fiber content in pistachios may cause discomfort for some with sensitive digestive systems.
Those taking blood thinners: Pistachios are high in vitamin K, which can interfere with blood-thinning medications like warfarin.
Individuals with a history of diverticulitis: Small nut particles can potentially irritate diverticula in the colon.
People with difficulty swallowing: Whole pistachios can pose a choking hazard for some individuals.
Those with pistachio sensitivity: Some people may experience digestive discomfort or other mild symptoms when consuming pistachios.
Individuals on a low-potassium diet: Pistachios are high in potassium, which may be a concern for those with certain kidney conditions.Remember, it’s always best to consult with a healthcare professional or registered dietitian for personalized advice regarding diet restrictions or concerns.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.