Is Pizza Sauce Gluten Free?
Most traditional pizza sauces are naturally gluten-free, as they are typically made from tomatoes, herbs, and spices. However, it’s always important to check the specific ingredients list or with the manufacturer, as some commercial pizza sauces may contain additives or thickeners that could potentially include gluten.

Rich in lycopene: Tomatoes, the main ingredient in pizza sauce, are high in lycopene, a powerful antioxidant that may help reduce the risk of certain cancers and heart disease.
Source of vitamins: Pizza sauce contains vitamins A and C, which support immune function and skin health.
Provides minerals: It offers small amounts of minerals like potassium, which is important for heart and muscle function.
Low in calories: When used in moderation, pizza sauce adds flavor without significantly increasing calorie content.
Contains fiber: The tomatoes in pizza sauce provide some dietary fiber, which aids digestion and promotes feelings of fullness.
Offers antioxidants: Besides lycopene, pizza sauce contains other antioxidants that help combat oxidative stress in the body.
May have anti-inflammatory properties: Some compounds in tomatoes have been associated with reducing inflammation in the body.
Supports heart health: The combination of lycopene, potassium, and fiber may contribute to better heart health.
Enhances nutrient absorption: The small amount of fat in pizza sauce can help with the absorption of fat-soluble vitamins and other nutrients.
Versatile ingredient: Pizza sauce can be used in various dishes, potentially increasing vegetable consumption in the diet.Remember that these benefits are most pronounced when the sauce is made with minimal added sugars and salts, and when consumed as part of an overall healthy diet.
Those with tomato allergies, as most pizza sauces are tomato-based
Individuals with acid reflux or GERD (Gastroesophageal reflux disease)
People with nightshade sensitivities (tomatoes are part of the nightshade family)
Those on a low-sodium diet, as many commercial pizza sauces are high in salt
Individuals with IBS (Irritable Bowel Syndrome) who find tomato-based products trigger symptoms
People with histamine intolerance, as tomatoes are high in histamines
Those following a low-carb or ketogenic diet, due to the natural sugars in tomatoes
Individuals with certain autoimmune conditions who find nightshades inflammatory
People with severe gastritis or stomach ulcers
Those following a low-FODMAP diet, especially if the sauce contains garlic or onions
Individuals with lycopene sensitivity (lycopene is abundant in tomatoes)Remember, the level of tolerance can vary among individuals, and it’s always best to consult with a healthcare professional or nutritionist for personalized advice.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently Asked Questions
Our Expert
Drs. Ilse van Asperen
Drs. Ilse van Asperen is a medical doctor specialising in orthomolecular therapy and nutritional coaching. With a background in public and clinical health research and management, she focuses on addressing the root causes of health issues through diet, gut health, and stress reduction. As a professional editor for Little Helpers, she reviews all gluten-free content to ensure accuracy, safety, and scientific credibility. More about me
Our Sources
The information on this page is based on reputable health and nutrition organisations, ensuring accuracy and reliability for anyone following a gluten-free diet. For further details, see the sources below.
Sources
Experiences of our customers
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.