Is Proper 12 Gluten Free?
Proper No. Twelve Irish Whiskey is generally considered gluten-free. As it is distilled from grains, the distillation process typically removes gluten proteins, making the final product safe for most people with gluten sensitivities or celiac disease.

Low in Carbohydrates and Sugar (When Consumed Neat)
Proper No. Twelve whiskey, like most distilled spirits, contains no carbohydrates or sugars when consumed neat (straight) or with low-calorie mixers like soda water. This makes it a suitable option for those who are following a low-carb or keto diet, or for individuals watching their sugar intake.
Antioxidant Properties
Whiskey, including Proper No. Twelve, contains antioxidants such as ellagic acid, which comes from the oak barrels used in the aging process. Antioxidants help to neutralize free radicals in the body, reducing oxidative stress and potentially protecting cells from damage. While the amount of antioxidants in whiskey is low compared to fruits and vegetables, it still provides some protective compounds.
Relaxation and Stress Relief
Whiskey, like Proper No. Twelve, can promote relaxation and stress relief when consumed in moderation. Alcohol acts as a central nervous system depressant, which can help reduce feelings of stress and anxiety, allowing you to unwind after a long day. Many people enjoy whiskey in social settings or during moments of leisure, which contributes to relaxation and overall well-being.
Digestive Aid (in Small Amounts)
Whiskey has traditionally been consumed as a digestif, a drink enjoyed after a meal to aid digestion. Some believe that whiskey can help stimulate the production of digestive enzymes, easing digestion, especially after heavy meals. While the scientific support for this is limited, some people find that small amounts of whiskey have a soothing effect on the stomach.
Fewer Additives (Compared to Other Alcoholic Drinks)
Proper No. Twelve is crafted through a natural distillation and aging process, containing fewer additives compared to many flavored alcoholic beverages or cocktails. Its rich flavor comes from aging in oak barrels, rather than artificial sweeteners or flavors, making it a more natural option for those looking to avoid heavily processed drinks.
Pregnant women or those trying to conceive
People under the legal drinking age (which varies by country)
Individuals with alcohol use disorder or a history of alcohol abuse
People taking medications that interact negatively with alcohol
Those with certain medical conditions, such as liver disease or pancreatitis
Individuals who are operating vehicles or machinery
People with a family history of alcoholism who are at higher risk for developing alcohol use disorder
Those who are in recovery from alcohol addiction
Individuals with certain mental health conditions that can be exacerbated by alcohol use
People who are fasting or on specific diets that prohibit alcohol consumption
Those who have religious or personal beliefs that preclude alcohol consumption
Individuals who are about to engage in activities requiring full concentration and coordination
People who are responsible for the care and safety of others at the timeRemember, if you’re unsure whether you should consume alcohol, it’s always best to consult with a healthcare professional.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
Asked Questions 1
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.