Is Pumpkin Pie Gluten Free?
Traditional pumpkin pie typically contains gluten in its crust, which is usually made with wheat flour. However, gluten-free versions of pumpkin pie can be made using alternative flours for the crust or by preparing a crustless pumpkin custard.

High in vitamin A, which supports eye health and immune function
Good source of fiber, aiding digestion and promoting feelings of fullness
Contains antioxidants like alpha-carotene, beta-carotene, and beta-cryptoxanthin
Provides potassium, which helps regulate blood pressure
Contains vitamin C, supporting immune health and collagen production
Offers calcium for bone health (especially if made with milk)
Provides iron, which is essential for blood health
Contains zinc, supporting immune function and wound healing
Offers some protein, particularly if made with eggs and milk
Low in calories compared to many other desserts
Can be a good source of healthy fats if made with nuts or seeds
Contains cinnamon, which may help regulate blood sugar
Provides manganese, important for bone health and wound healingRemember that these benefits primarily come from the pumpkin and spices; the crust and added sugars can offset some of these benefits if consumed in excess.
Those with pumpkin allergies: Some people may be allergic to pumpkin or other squash varieties.
Individuals with severe nut allergies: Many pumpkin pie recipes include nuts or may be processed in facilities that handle nuts.
People with egg allergies: Traditional pumpkin pie recipes typically include eggs.
Those with dairy allergies or lactose intolerance: Pumpkin pie often contains milk or cream.
Individuals with gluten sensitivities or celiac disease: The pie crust is usually made with wheat flour.
People with diabetes or on low-sugar diets: Pumpkin pie is high in sugar and carbohydrates.
Those on low-calorie diets: Pumpkin pie can be calorie-dense.
Individuals with cinnamon allergies: Pumpkin pie spice often includes cinnamon.
People with certain gastrointestinal conditions: The high fiber content in pumpkin may cause discomfort for some.
Those taking certain medications: The vitamin K in pumpkin can interfere with blood-thinning medications.
Individuals following specific religious or cultural dietary restrictions: Some may avoid certain ingredients used in pumpkin pie.Remember, many of these concerns can be addressed with alternative recipes or ingredients, so always consult with a healthcare professional for personalized dietary advice.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently Asked Questions
Our Expert
Drs. Ilse van Asperen
Drs. Ilse van Asperen is a medical doctor specialising in orthomolecular therapy and nutritional coaching. With a background in public and clinical health research and management, she focuses on addressing the root causes of health issues through diet, gut health, and stress reduction. As a professional editor for Little Helpers, she reviews all gluten-free content to ensure accuracy, safety, and scientific credibility. More about me
Our Sources
The information on this page is based on reputable health and nutrition organisations, ensuring accuracy and reliability for anyone following a gluten-free diet. For further details, see the sources below.
Sources
Experiences of our customers
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.