Is Ragu Spaghetti Sauce Gluten Free?
Ragu Spaghetti Sauce is generally considered gluten-free, as its main ingredients typically do not contain gluten. However, it’s always best to check the specific product label for the most up-to-date information, as ingredients and manufacturing processes can change over time.

Source of lycopene: Tomatoes, the main ingredient, are rich in lycopene, an antioxidant that may help reduce the risk of certain cancers and heart disease.
Vitamin C: Tomatoes provide vitamin C, which supports immune function and helps with iron absorption.
Vitamin A: Some varieties may contain vitamin A, which is important for eye health and immune function.
Low in calories: Generally, tomato-based pasta sauces are relatively low in calories compared to cream-based sauces.
Some fiber: Tomatoes contain small amounts of dietary fiber, which aids digestion.
Potential herbs and spices: Depending on the variety, it may contain herbs and spices that have their own health benefits.
Convenience: It’s an easy way to add vegetables to a meal, which can contribute to overall nutritional intake.
Low in fat: Most varieties are low in fat, especially compared to other sauce options.
No cholesterol: Being plant-based, it contains no cholesterol.
Hydration: The high water content in tomatoes contributes to hydration.It’s important to note that store-bought sauces often contain added sugars and sodium, so it’s always best to check the nutrition label and consume in moderation as part of a varied diet.
Individuals with tomato allergies
People with severe acid reflux or GERD (Gastroesophageal reflux disease)
Those on a low-sodium diet (some varieties can be high in sodium)
Individuals with onion or garlic sensitivities (as these are common ingredients)
People with certain digestive disorders who are sensitive to acidic foods
Those following a low-carb or keto diet (due to sugar content in some varieties)
Individuals with nightshade sensitivities (tomatoes are part of the nightshade family)
People with sulfite sensitivities (if the sauce contains preservatives)
Those following a strict vegan diet (some varieties may contain animal-derived ingredients)
Individuals with celiac disease or gluten sensitivities (always check labels, as some varieties may contain gluten)
People trying to avoid added sugars in their diet
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently Asked Questions
Our Expert
Drs. Ilse van Asperen
Drs. Ilse van Asperen is a medical doctor specialising in orthomolecular therapy and nutritional coaching. With a background in public and clinical health research and management, she focuses on addressing the root causes of health issues through diet, gut health, and stress reduction. As a professional editor for Little Helpers, she reviews all gluten-free content to ensure accuracy, safety, and scientific credibility. More about me
Our Sources
The information on this page is based on reputable health and nutrition organisations, ensuring accuracy and reliability for anyone following a gluten-free diet. For further details, see the sources below.
Sources
Experiences of our customers
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.