No, rye bread is not gluten-free. Rye contains a protein called secalin, which is a form of gluten, making rye bread unsuitable for those with celiac disease or gluten sensitivity.

Lower glycemic index compared to wheat bread, which can help manage blood sugar levels
High in fiber, promoting digestive health and feelings of fullness
Rich in various vitamins and minerals, including B vitamins, iron, and magnesium
Contains more soluble fiber than wheat bread, which may help lower cholesterol levels
Potentially beneficial for weight management due to its satiating properties
Contains lignans, which are antioxidants that may help reduce the risk of certain cancers
May improve insulin sensitivity, which is beneficial for diabetes management
Often contains less gluten than wheat bread, making it easier to digest for some people
Can contribute to heart health due to its fiber and nutrient content
Typically has a lower calorie density compared to white bread
May help regulate bowel movements due to its high fiber contentRemember that the exact nutritional profile can vary depending on the specific recipe and preparation method.
People with celiac disease, as rye contains gluten
Individuals with non-celiac gluten sensitivity
Those with a rye allergy
People following a low FODMAP diet, as rye is high in fructans
Individuals with irritable bowel syndrome (IBS) who are sensitive to fructans
People on a low-carb or ketogenic diet, due to rye bread’s high carbohydrate content
Those with wheat allergy, as rye is often cross-contaminated with wheat during processing
Individuals with a yeast allergy, if the rye bread contains yeast
People with diabetes who need to closely monitor their carbohydrate intake
Those following a grain-free diet for various health reasons
Individuals with certain gastrointestinal disorders that require limiting fiber intake
People with specific enzyme deficiencies that affect grain digestionIt’s important to note that while these groups should generally avoid or limit rye bread, individual tolerances may vary, and it’s best to consult with a healthcare professional for personalized advice.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
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Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.