Rye flour is not gluten-free, as rye contains a protein called secalin which is a form of gluten. People with celiac disease or gluten sensitivity should avoid rye flour and products made with it.

High in fiber: Rye flour is an excellent source of dietary fiber, which aids digestion and promotes gut health.
Low glycemic index: It causes a slower, more gradual rise in blood sugar compared to wheat flour, making it beneficial for diabetes management.
Rich in nutrients: Rye flour contains essential minerals like magnesium, phosphorus, zinc, iron, and B-vitamins.
Weight management: The high fiber content helps you feel fuller for longer, potentially aiding in weight control.
Heart health: The fiber in rye flour may help lower cholesterol levels and reduce the risk of heart disease.
Antioxidant properties: Rye contains phenolic compounds that act as antioxidants, protecting cells from damage.
May reduce inflammation: Some studies suggest rye may have anti-inflammatory properties.
Supports digestive health: The fiber in rye can promote regular bowel movements and support a healthy gut microbiome.
Potential cancer-fighting properties: Some research indicates that rye may have protective effects against certain types of cancer.
Gluten alternative: While not gluten-free, rye contains less gluten than wheat, making it a potential alternative for some with mild gluten sensitivities.
Blood sugar control: The complex carbohydrates in rye flour can help stabilize blood sugar levels.Remember, while rye flour offers these potential benefits, it’s important to consume it as part of a balanced diet.
People with celiac disease, as rye contains gluten which can trigger severe reactions
Individuals with non-celiac gluten sensitivity
Those with a wheat allergy, as there’s a risk of cross-reactivity
People following a gluten-free diet for other health reasons
Individuals with a specific rye allergy
Those with irritable bowel syndrome (IBS) who are sensitive to FODMAPs, as rye is high in fructans
People on a low-carb or ketogenic diet, due to rye’s high carbohydrate content
Individuals with a condition called ergotism, which is caused by fungal contamination sometimes found in rye
Those with phenylketonuria (PKU), as rye contains phenylalanine
People with certain gastrointestinal disorders who are advised to follow a low-fiber dietRemember, it’s always best to consult with a healthcare professional or registered dietitian before making significant changes to your diet, especially if you have specific health concerns or conditions.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.