Is Safflower Oil Gluten Free?
Yes, safflower oil is gluten-free. As a pure vegetable oil extracted from safflower seeds, it does not contain any gluten proteins, which are typically found in wheat, barley, and rye.

High in heart-healthy unsaturated fats
May help lower cholesterol levels
Could improve insulin sensitivity and blood sugar control
Potential anti-inflammatory properties
May aid in weight loss and fat reduction
Rich in vitamin E, an antioxidant
Could promote skin health and wound healing
May help reduce the risk of heart disease
Possible benefits for hair health and growth
Could support bone health
May help regulate menstrual cycles in women
Potential to boost immune system function
Might improve cognitive function and brain health
Could aid in managing blood pressure
May have anti-cancer properties (though more research is needed)It’s important to note that while these benefits have been associated with safflower oil, more research is needed to fully understand its effects. Always consult with a healthcare professional before making significant changes to your diet or health regimen.
Individuals with a known allergy to safflower or other plants in the Asteraceae family (such as daisies, ragweed, or chrysanthemums)
People with bleeding disorders or those taking blood-thinning medications, as safflower oil may increase bleeding risk
Individuals scheduled for surgery, due to its potential blood-thinning effects
Those with diabetes, as safflower oil may affect blood sugar levels
People with liver disease, as the liver processes fats and oils
Individuals with gallbladder issues or those who have had their gallbladder removed
Pregnant women, unless advised otherwise by their healthcare provider
Breastfeeding mothers, as there’s limited research on its effects during lactation
People with a history of hormone-sensitive cancers (e.g., breast, ovarian, or prostate cancer), as safflower oil may have estrogenic effects
Individuals with high triglyceride levels, as some types of safflower oil may increase triglycerides
Those following a low-fat diet for medical reasons
People with inflammatory conditions, as some types of safflower oil are high in omega-6 fatty acids, which may promote inflammation in large amountsAlways consult with a healthcare professional before making significant changes to your diet, especially if you have any medical conditions or concerns.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
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Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.