Sourdough bread is not inherently gluten-free, as it is typically made with wheat flour which contains gluten. However, the fermentation process in sourdough bread can break down some of the gluten proteins, potentially making it easier to digest for some people with mild gluten sensitivities, though it is still not safe for those with celiac disease or severe gluten intolerance.

Easier to digest due to the fermentation process
Lower glycemic index compared to regular bread
Contains prebiotics, which support gut health
Higher in nutrients and minerals due to fermentation
Lower phytate levels, allowing for better mineral absorption
Potential probiotic benefits from beneficial bacteria
May help regulate blood sugar levels
Can be lower in calories than some commercial breads
May have a positive effect on the body’s insulin response
The lactic acid in sourdough improves the body’s ability to absorb nutrients, especially calcium and magnesium.Remember that while sourdough bread offers these potential benefits, it’s still important to consume it in moderation as part of a balanced diet.
People with celiac disease (if the sourdough is made with wheat, rye, or barley)
Individuals with non-celiac gluten sensitivity
Those with a wheat allergy
People following a low-carb or ketogenic diet
Individuals with yeast allergies or sensitivities
Those on a low-FODMAP diet (during the elimination phase)
People with severe IBS who find fermented foods trigger symptoms
Individuals with candida overgrowth who are avoiding yeasts
Those following a paleo or grain-free diet
People with diabetes who need to closely monitor their carbohydrate intake
Individuals on a low-sodium diet (as bread can be a significant source of sodium)
Those with specific grain allergies (e.g., wheat, rye, spelt) used in the sourdoughRemember that sourdough can be made with various flours, so some of these restrictions may not apply to all types of sourdough bread. Always consult with a healthcare professional for personalized dietary advice.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
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Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.