Generally, soy sauce is not gluten-free as it is traditionally made with wheat as one of its main ingredients. However, there are gluten-free soy sauce alternatives available, such as tamari or coconut aminos, which are suitable for those following a gluten-free diet.

Low in calories: Generally low in calories, making it a good option for flavor without adding many calories
Rich in antioxidants: Contains antioxidants that may help protect against cell damage
Source of protein: Provides small amounts of protein
Contains essential amino acids: Offers all essential amino acids, though in small quantities
May have anti-allergenic properties: Some studies suggest it might help reduce allergic reactions
Potential digestive aid: May help stimulate digestion due to its fermented nature
Contains some minerals: Provides small amounts of iron, manganese, and magnesium
Potential probiotic benefits: Unpasteurized versions may contain beneficial bacteria
May help reduce blood pressure: Some studies suggest it might have a positive effect on blood pressure
Soy sauce is a good source of choline, an essential nutrient that supports brain function and nerve communicationRemember that while soy sauce has these potential benefits, it’s also high in sodium, so it should be consumed in moderation as part of a balanced diet.
People with high blood pressure: Due to its high sodium content
Individuals on a low-sodium diet: For health reasons or as advised by a doctor
Those with soy allergies: Soy sauce is made from soybeans and can trigger allergic reactions
People with gluten sensitivities or celiac disease: Many soy sauces contain wheat
Individuals with certain gastrointestinal conditions: Such as IBS or acid reflux, as soy sauce can be an irritant
Those taking monoamine oxidase inhibitors (MAOIs): Soy sauce contains tyramine, which can interact with these medications
Individuals with histamine intolerance: Soy sauce is high in histamines
People with gout: Due to its high purine content
Those with thyroid issues: Soy products can interfere with thyroid hormone absorption
Individuals trying to reduce their intake of processed foods: As soy sauce is a highly processed condiment
Babies and young children: Due to its high sodium content and potential allergensRemember, it’s always best to consult with a healthcare professional or registered dietitian for personalized advice regarding dietary restrictions or concerns.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
Asked Questions 1
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.