Is Spaghetti Sauce Gluten Free?
Generally, traditional tomato-based spaghetti sauce is gluten-free as it’s typically made from ingredients like tomatoes, herbs, and spices that don’t contain gluten. However, it’s important to always check the label or ingredients list, as some commercially prepared sauces may contain additives or thickeners that could include gluten.

Rich in lycopene: A powerful antioxidant that may reduce the risk of certain cancers and heart disease
Good source of vitamins: Particularly vitamin C and vitamin A, which support immune function and eye health
Provides minerals: Such as potassium, which helps regulate blood pressure
Contains fiber: Aids in digestion and promotes feelings of fullness
Low in calories: When made with minimal added oils or sugars
Offers anti-inflammatory properties: Due to various compounds in tomatoes
May improve heart health: Thanks to its combination of nutrients and antioxidants
Supports bone health: Due to the presence of vitamin K and calcium in some recipes
Can be a good source of protein: When meat or legumes are included
Versatile for incorporating vegetables: Allowing for increased nutrient intake
May help lower blood pressure: Due to its potassium content
Potentially aids in weight management: When used as part of a balanced dietRemember that the specific health benefits can vary depending on the ingredients used and preparation method of the spaghetti sauce.
People with tomato allergies, as most spaghetti sauces are tomato-based
Individuals with acid reflux or GERD, due to the high acidity of tomatoes
Those with nightshade sensitivities (tomatoes are part of the nightshade family)
People on low-carb or ketogenic diets, as some sauces may contain added sugars
Individuals with severe gluten sensitivities, if the sauce contains gluten as a thickener
Those with onion or garlic allergies, as these are common ingredients in many spaghetti sauces
People on low-sodium diets, as many commercial sauces are high in salt
Individuals with IBS or other digestive issues who are sensitive to acidic foods
Those following a strict low-FODMAP diet, as onions and garlic are high in FODMAPs
People with histamine intolerance, as tomatoes are high in histamines
Individuals trying to avoid lycopene for medical reasons (though lycopene is generally beneficial)
Those with specific herb allergies, if the sauce contains herbs they’re allergic toRemember, many of these issues can be addressed by making homemade sauce with controlled ingredients or finding specialized commercial options.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
Asked Questions 1
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.