Is Splenda Gluten Free?
Yes, Splenda (sucralose) is gluten-free. It does not contain any wheat, barley, rye, or other gluten-containing ingredients.

Zero calories: Splenda doesn’t contribute to calorie intake, which can be beneficial for weight management.
No effect on blood sugar: It doesn’t raise blood glucose levels, making it a potential option for people with diabetes.
Tooth-friendly: Unlike sugar, Splenda doesn’t contribute to tooth decay.
Versatility in cooking: It can be used in baking and cooking, allowing for reduced-calorie versions of many foods.
No carbohydrates: Useful for those following low-carb diets.
Heat stable: It doesn’t break down when exposed to high temperatures, maintaining its sweetness in cooking.
May aid in weight loss: When used to replace sugar, it can help reduce overall calorie intake.
No known adverse effects on gut bacteria: Unlike some other artificial sweeteners, sucralose is not thought to significantly alter gut microbiome.
FDA approved: It has been deemed safe for consumption by the U.S. Food and Drug Administration.However, it’s important to note that while these potential benefits exist, excessive consumption of any artificial sweetener is not recommended, and some studies suggest possible negative effects with long-term, high-dose use. Always consult with a healthcare professional for personalized advice.
Individuals with phenylketonuria (PKU): Splenda contains phenylalanine, which can be harmful to those with PKU.
People with known allergies or sensitivities to sucralose or any of its ingredients.
Those with gastrointestinal issues: Some people report digestive discomfort after consuming Splenda.
Pregnant or breastfeeding women: While considered safe, there’s limited research on long-term effects.
Children: The long-term effects of artificial sweeteners on developing bodies are not fully known.
Individuals with migraines: Some people report that artificial sweeteners, including Splenda, can trigger migraines.
Those with diabetes: While Splenda doesn’t affect blood sugar directly, it may influence insulin sensitivity in some individuals.
People trying to reduce their cravings for sweet foods: Artificial sweeteners may maintain or increase cravings for sweet tastes.
Individuals concerned about potential long-term health effects: Some prefer to avoid artificial sweeteners due to ongoing debates about their long-term safety.
Those following a whole foods or natural diet: Splenda is an artificial sweetener and doesn’t align with these dietary approaches.Remember, it’s always best to consult with a healthcare professional or registered dietitian for personalized advice on dietary choices.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
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Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.