Is Synthroid Gluten Free?
Synthroid, a brand name for levothyroxine, is generally considered gluten-free by the manufacturer. However, individuals with celiac disease or severe gluten sensitivity should consult their doctor or pharmacist to confirm the gluten-free status of their specific prescription, as formulations can sometimes change or vary between manufacturers.

Restores normal thyroid hormone levels in people with hypothyroidism
Improves energy levels and reduces fatigue
Helps regulate metabolism, potentially aiding in weight management
Improves mood and reduces symptoms of depression associated with hypothyroidism
Enhances cognitive function, including memory and concentration
Promotes healthy hair growth and reduces hair loss
Improves skin health and reduces dryness
Supports proper heart function and helps maintain a healthy heart rate
Assists in regulating body temperature
Helps maintain healthy cholesterol levels
Supports proper growth and development in children with hypothyroidism
May improve fertility in women with thyroid-related infertility issues
Helps prevent goiter (enlargement of the thyroid gland)
Supports proper bone health and helps prevent osteoporosis
Improves digestive function and reduces constipation associated with hypothyroidism.
It’s important to note that Synthroid should only be taken under the supervision of a healthcare professional, as proper dosing is crucial for achieving these benefits and avoiding potential side effects.
People with untreated adrenal insufficiency
Those with uncorrected thyrotoxicosis (overactive thyroid)
Individuals with acute myocardial infarction (heart attack)
People with known hypersensitivity to levothyroxine or any of its inactive ingredients
Patients with untreated subclinical (mild) hyperthyroidism
Those with an autonomous thyroid gland
Individuals with a history of thyroid cancer, unless directed by their doctor
Pregnant women, unless specifically prescribed by their healthcare provider
People with certain heart conditions, such as angina or hypertension, without proper medical supervision
Individuals with diabetes, as Synthroid may affect blood sugar levels and insulin requirements
Those taking certain medications that may interact with Synthroid, such as: – Calcium supplements – Iron supplements – Certain antacids – Some cholesterol-lowering drugs – Certain seizure medicationsAlways consult with a healthcare professional before starting or stopping any medication, as individual circumstances may vary.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
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Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.