Is Wheat Flour Gluten Free?
Wheat flour is not gluten-free, as wheat naturally contains gluten proteins. Individuals with celiac disease or gluten sensitivity should avoid wheat flour and opt for gluten-free alternatives such as rice flour, almond flour, or coconut flour.

Rich in fiber, which aids digestion and promotes gut health
Good source of complex carbohydrates for sustained energy
Contains essential B vitamins, including thiamin, riboflavin, niacin, and folate
Provides minerals such as iron, magnesium, and zinc
Contains antioxidants, particularly in whole wheat flour
May help in weight management due to its fiber content and ability to promote satiety
Can contribute to heart health by potentially lowering cholesterol levels
Provides protein, which is essential for muscle building and repair
Contains selenium, which supports thyroid function and immune system
May help regulate blood sugar levels due to its lower glycemic index compared to refined flours
Whole wheat flour contains phytochemicals that may have anti-inflammatory properties
Can contribute to overall nutrient intake as part of a balanced diet
May reduce the risk of certain chronic diseases when consumed as part of a healthy lifestyleNote that these benefits are most pronounced in whole wheat flour, as refined wheat flour loses some nutrients during processing. Additionally, individuals with gluten sensitivities or celiac disease should avoid wheat flour.
People with celiac disease
Individuals with non-celiac gluten sensitivity
Those with wheat allergy
People following a gluten-free diet for other health reasons
Individuals with irritable bowel syndrome (IBS) who are sensitive to wheat
Those with wheat intolerance
People with dermatitis herpetiformis (a skin condition associated with gluten sensitivity)
Individuals following a low FODMAP diet
Those with certain autoimmune disorders who find wheat exacerbates their symptoms
People with gluten ataxia (a neurological condition triggered by gluten)
Individuals trying to manage inflammation through diet (as wheat can be pro-inflammatory for some)
Those following specific diets that exclude grains or carbohydrates (e.g., paleo, keto)Remember, it’s always best to consult with a healthcare professional or registered dietitian before making significant changes to your diet.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently Asked Questions
Our Expert
Drs. Ilse van Asperen
Drs. Ilse van Asperen is a medical doctor specialising in orthomolecular therapy and nutritional coaching. With a background in public and clinical health research and management, she focuses on addressing the root causes of health issues through diet, gut health, and stress reduction. As a professional editor for Little Helpers, she reviews all gluten-free content to ensure accuracy, safety, and scientific credibility. More about me
Our Sources
The information on this page is based on reputable health and nutrition organisations, ensuring accuracy and reliability for anyone following a gluten-free diet. For further details, see the sources below.
Sources
Experiences of our customers
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.