Whole grain oat flour is naturally gluten-free. However, oats can be contaminated with gluten during growing or processing, so it’s important to look for oat flour specifically labeled as gluten-free if you have celiac disease or gluten sensitivity.

High in fiber, which aids digestion and promotes gut health
Contains beta-glucan, a soluble fiber that can help lower cholesterol levels
May help reduce the risk of heart disease
Can assist in blood sugar control and diabetes management
Rich in antioxidants, particularly avenanthramides, which have anti-inflammatory properties
Good source of essential minerals like iron, magnesium, and zinc
Provides complex carbohydrates for sustained energy release
Contains protein, which supports muscle growth and repair
May help in weight management by promoting feelings of fullness
Gluten-free (when processed in a gluten-free facility), making it suitable for people with celiac disease or gluten sensitivity
Contains vitamins B1 (thiamin) and B5 (pantothenic acid)
May help reduce blood pressure
Supports bone health due to its calcium and phosphorus content
Can contribute to a healthy immune system
May have prebiotic properties, supporting beneficial gut bacteriaRemember that while whole grain oat flour offers these potential benefits, it should be consumed as part of a balanced diet for optimal health.
Individuals with celiac disease: Although oats are naturally gluten-free, they are often processed in facilities that also handle wheat, barley, and rye, leading to potential cross-contamination.
People with non-celiac gluten sensitivity: Some individuals may experience symptoms similar to celiac disease when consuming gluten-containing grains, including contaminated oats.
Those with oat allergies: While rare, some people may have a specific allergy to oats.
Individuals following a low-carb or ketogenic diet: Oat flour is relatively high in carbohydrates, which may not align with these dietary approaches.
People with avenin sensitivity: Avenin is a protein in oats that can cause reactions in some sensitive individuals.
Those with digestive issues: Some people with irritable bowel syndrome (IBS) or other digestive disorders may find that oats exacerbate their symptoms.
Individuals on a low-fiber diet: Oat flour is high in fiber, which may not be suitable for those temporarily restricting fiber intake due to certain medical conditions or procedures.
People with diabetes who are not monitoring their carbohydrate intake: Oat flour can affect blood sugar levels, so portion control and monitoring may be necessary.
Those with phenylketonuria (PKU): Oats contain phenylalanine, which individuals with PKU need to limit or avoid.Always consult with a healthcare professional or registered dietitian before making significant changes to your diet, especially if you have any health concerns or conditions.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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