Whole grain rolled oats are naturally gluten-free. However, they may be contaminated with gluten during processing or packaging, so it’s important to look for oats specifically labeled as gluten-free if you have celiac disease or gluten sensitivity.

Rich in fiber, promoting digestive health and regularity
High in beta-glucan, a soluble fiber that helps lower cholesterol levels
May reduce the risk of heart disease
Helps control blood sugar levels, beneficial for diabetes management
Provides sustained energy due to complex carbohydrates
Good source of important vitamins and minerals, including B vitamins, iron, and magnesium
Contains antioxidants, particularly avenanthramides, which have anti-inflammatory properties
Supports weight management by promoting feelings of fullness
May reduce the risk of certain types of cancer, particularly colorectal cancer
Gluten-free (when processed in a gluten-free facility), suitable for people with celiac disease or gluten sensitivity
Supports healthy gut bacteria, promoting overall digestive health
May help reduce blood pressure
Contains protein, supporting muscle health and repair
Low in fat and calories, making it a nutrient-dense food choice
May help boost the immune system due to its nutrient profile
Potentially beneficial for skin health due to its antioxidant content
People with celiac disease: Although oats are naturally gluten-free, they are often processed in facilities that also handle wheat, barley, and rye, leading to potential cross-contamination.
Individuals with non-celiac gluten sensitivity: Some people may experience symptoms similar to celiac disease when consuming oats, even if they don’t have celiac disease.
Those with oat allergies: While rare, some people may be allergic to oats and should avoid them entirely.
People following a low FODMAP diet: Oats contain FODMAPs, which may cause digestive issues for some individuals with irritable bowel syndrome (IBS) or other digestive disorders.
Individuals on a very low-carb or ketogenic diet: Oats are relatively high in carbohydrates and may not fit into these dietary plans.
People with avenin sensitivity: Some individuals may be sensitive to avenin, a protein found in oats, which can cause inflammation in sensitive individuals.
Those with difficulty swallowing or at risk of choking: Whole grain rolled oats may pose a choking hazard for these individuals if not properly prepared.
Individuals with certain gastrointestinal disorders: Some people with conditions like inflammatory bowel disease (IBD) may need to limit their intake of high-fiber foods like oats during flare-ups.
People taking certain medications: Oats may interact with some medications, so it’s best to consult a healthcare provider if you’re on any prescription drugs.
Those with a history of kidney stones: Oats are high in oxalates, which may contribute to kidney stone formation in susceptible individuals.It’s always best to consult with a healthcare professional or registered dietitian before making significant changes to your diet, especially if you have any health concerns or conditions.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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