Yes, whole grain sorghum flour is naturally gluten-free. It’s a safe option for people with celiac disease or gluten sensitivity, as sorghum is not a wheat, barley, rye, or related grain that contains gluten proteins.

Gluten-free: Suitable for people with celiac disease or gluten sensitivity
High in fiber: Promotes digestive health and helps maintain regular bowel movements
Rich in antioxidants: Contains phenolic compounds that may help reduce inflammation and oxidative stress
Good source of protein: Provides essential amino acids for muscle building and repair
Contains essential minerals: Includes iron, phosphorus, magnesium, and zinc for various bodily functions
Low glycemic index: May help in blood sugar management and weight control
Heart-healthy: Contains plant sterols that may help lower cholesterol levels
Source of B vitamins: Provides thiamin, riboflavin, and niacin for energy metabolism
Contains beneficial plant compounds: Such as tannins and anthocyanins, which may have anti-inflammatory properties
Supports bone health: Contains calcium and magnesium, important for bone structure and strength
May have anti-cancer properties: Some studies suggest potential anti-cancer effects due to its antioxidant content
Helps with weight management: High fiber content promotes feelings of fullness and satiety
Supports immune function: Contains vitamins and minerals that play a role in immune system healthRemember that while these benefits are associated with whole grain sorghum flour, individual responses may vary, and it’s always best to consult with a healthcare professional for personalized dietary advice.
People with celiac disease or non-celiac gluten sensitivity: Although sorghum is naturally gluten-free, there’s a risk of cross-contamination during processing. Always ensure the product is certified gluten-free.
Individuals with grain allergies: Though rare, some people may be allergic to sorghum.
Those with digestive sensitivities: Some people may experience bloating or gas when consuming sorghum, especially if they’re not used to high-fiber foods.
People on low-carb or ketogenic diets: Sorghum flour is high in carbohydrates and may not fit into these dietary plans.
Individuals with FODMAPs sensitivities: Sorghum contains FODMAPs, which can cause digestive issues for some people.
Those with compromised immune systems: There’s a slight risk of mold contamination in grains, so immunocompromised individuals should be cautious.
People taking certain medications: Sorghum may interact with some medications, so it’s best to consult a healthcare provider.
Individuals with diabetes: While sorghum has a lower glycemic index than some grains, those with diabetes should monitor their intake and blood sugar levels.
People with a history of oxalate kidney stones: Sorghum contains oxalates, which could contribute to kidney stone formation in susceptible individuals.Always consult with a healthcare professional or registered dietitian if you have concerns about incorporating sorghum flour into your diet.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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