Is Whole Grain Wheat Gluten Free?
Whole grain wheat is not gluten-free. Wheat naturally contains gluten proteins, which are present in all forms of wheat including whole grain varieties.

High in fiber, which aids digestion and promotes regular bowel movements
Rich in B vitamins, including niacin, thiamin, and folate
Good source of minerals like iron, magnesium, and zinc
Contains antioxidants that may help reduce the risk of chronic diseases
May help lower the risk of heart disease
Can assist in weight management due to its filling nature
Helps regulate blood sugar levels, which is beneficial for diabetes management
Provides a steady release of energy, helping to maintain stable blood sugar levels
May reduce the risk of certain types of cancer, particularly colon cancer
Supports gut health by promoting the growth of beneficial bacteria
Contains phytochemicals that may have anti-inflammatory properties
May help reduce the risk of stroke
Supports healthy brain function due to its vitamin E content
Can contribute to stronger bones due to its mineral content
May help lower cholesterol levels, particularly LDL (bad) cholesterolRemember, these benefits are most pronounced when whole grain wheat is consumed as part of a balanced, healthy diet.
People with celiac disease
Those with non-celiac gluten sensitivity
Individuals with wheat allergy
People with irritable bowel syndrome (IBS) who are sensitive to FODMAPs
Those following a low-carb or ketogenic diet
Individuals with specific digestive disorders like Crohn’s disease or ulcerative colitis (in some cases)
People with wheat intolerance
Those following a Paleo diet
Individuals trying to reduce lectins in their diet
People with certain autoimmune conditions who find relief from a wheat-free diet
Those with dermatitis herpetiformis (a skin manifestation of celiac disease)
Individuals following a grain-free diet for personal health reasons
People with gluten ataxia (a neurological condition triggered by gluten)It’s important to note that for many of these conditions, the advice to avoid wheat should come from a healthcare professional after proper diagnosis.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
Asked Questions 1
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.