Is Wine Gluten Free?
Generally speaking, wine is gluten-free as it is made from fermented grapes, which do not contain gluten. However, some wines may have trace amounts of gluten due to certain production processes or additives, so those with severe gluten sensitivities should always check with the manufacturer or opt for wines specifically labeled as gluten-free.

Rich in antioxidants, especially red wine help protecting the lining of blood vessels in the heart
May reduce risk of heart disease
Potential to lower bad cholesterol levels
May help regulate blood sugar
Could improve brain function and reduce risk of dementia
Possible anti-aging properties due to resveratrol content
May reduce risk of certain types of cancer
Could help maintain bone density
Potential to reduce stress and promote relaxation
May improve digestion
Could boost immune system function
Possible reduction in risk of type 2 diabetes
Could help prevent vision loss
Potential to improve sleep qualityRemember, these benefits are generally associated with moderate consumption. Excessive alcohol intake can lead to numerous health problems and negate any potential benefits.
Pregnant women
Individuals with alcohol use disorders or a history of alcoholism
People taking certain medications that interact negatively with alcohol
Those with liver disease or other liver problems
Individuals with pancreatitis
People with certain heart conditions
Those with a history of stroke
Individuals with gout
People with certain mental health conditions that can be exacerbated by alcohol
Those who experience migraines triggered by alcohol
Individuals with sulfite allergies (as many wines contain sulfites)
People with histamine intolerance
Individuals on a strict calorie-controlled diet
Those who need to avoid sugar for medical reasons (some wines contain residual sugar)
People who are operating vehicles or machinery
Individuals under the legal drinking age
People with certain digestive disorders that are aggravated by alcoholRemember, it’s always best to consult with a healthcare professional for personalized advice regarding alcohol consumption.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently
Asked Questions 1
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.